3-methoxy-4-nitrophenol synthesis
- Product Name:3-methoxy-4-nitrophenol
- CAS Number:16292-95-8
- Molecular formula:C7H7NO4
- Molecular Weight:169.13
448-19-1
303 suppliers
$5.00/1g
16292-95-8
104 suppliers
$11.00/250mg
Yield: 95%
Reaction Conditions:
Stage #1:4-fluoro-2-methoxy-1-nitrobenzene with water;sodium hydroxide in dimethyl sulfoxide at 80; for 20 h;
Stage #2: with hydrogenchloride in water;dimethyl sulfoxide; pH=5 at 20;
Steps:
132.A
To a solution of 4-fluoro-2-methoxy-1-nitrobenzene (Combi-blocks, 3.4 g, 19.9 mmol) in DMSO (40 mL) was added an aqueous solution (1N) of NaOH (40 mL, 40 mmol). The reaction mixture was heated at 80° C. for 20 h. The mixture was cooled to room temperature, and the "pH” of the solution was adjusted to 5 by aqueous HCl solution. The mixture was extracted with ethyl acetate three times. The combined organic extract was washed with water, brine, dried over MgSO4, and concentrated to give 3-methoxy-4-nitrophenol as a light yellow solid (3.2 g, 95%).
References:
Bartkovitz, David Joseph;Chu, Xin-Jie;Ding, Qingjie;Graves, Bradford James;Jiang, Nan;Zhang, Jing;Zhang, Zhuming US2011/130398, 2011, A1 Location in patent:Page/Page column 60
150-19-6
355 suppliers
$6.00/5g
16292-95-8
104 suppliers
$11.00/250mg
394-41-2
301 suppliers
$16.00/1g
124-41-4
716 suppliers
$12.00/25g
16292-95-8
104 suppliers
$11.00/250mg
67-56-1
776 suppliers
$7.29/5ml-f
394-41-2
301 suppliers
$16.00/1g
16292-95-8
104 suppliers
$11.00/250mg
150-19-6
355 suppliers
$6.00/5g
3114-61-2
35 suppliers
$69.00/100mg
16292-95-8
104 suppliers
$11.00/250mg
704-14-3
136 suppliers
$7.00/1g