ChemicalBook CAS DataBase List 3-PHENOXYANILINE

3-PHENOXYANILINE synthesis

10synthesis methods

Product Name:3-PHENOXYANILINE
CAS Number:3586-12-7
Molecular formula:C12H11NO
Molecular Weight:185.22

591-19-5
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108-95-2 Synthesis

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3586-12-7
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$39.60/5g

Yield: 90%

Reaction Conditions:

with 1-Butylimidazole;potassium carbonate;copper(l) chloride in o-xylene at 140; for 20 h;Inert atmosphere;

Steps:

Synthesis of Intermediate 23a
Phenol (12 mmol), 3-bromoaniline (10 mmol), K2CO3 (20 mmol), 1-butyl-1H-imidazole (5 mmol),and CuCl (4.5 mmol) were added to o-xylene (10 mL) under Ar atmosphere, and the mixture washeated to 140 C for 20h. After cooling to room temperature, the mixture was filtered. The filtrate wasconcentrated under reduced pressure and purified by column chromatography (PE/EA=4:1, V/V) togive 23a in yield of 90%.

References:

Zeng, Fanxun;Quan, Lina;Yang, Guantian;Qi, Tiantian;Zhang, Letian;Li, Shiliang;Li, Honglin;Zhu, Lili;Xu, Xiaoyong [Molecules,2019,vol. 24,# 15,art. no. 2780]