3-Phenylthiophene-2-carboxylic Acid Methyl Ester synthesis

8synthesis methods

Product Name:3-Phenylthiophene-2-carboxylic Acid Methyl Ester
CAS Number:21676-89-1
Molecular formula:C12H10O2S
Molecular Weight:218.27

22288-78-4 Synthesis

22288-78-4
401 suppliers
$11.00/5g

4482-01-3
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$60.00/100mg

98-80-6 Synthesis

98-80-6
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$5.00/5g

3-Phenylthiophene-2-carboxylic Acid Methyl Ester

21676-89-1
9 suppliers
$120.00/10mg

Yield:21676-89-1 91%

Reaction Conditions:

Stage #1: Methyl 3-aminothiophene-2-carboxylate;o-benzenedisulfonimidewith acetic acid at 0 - 5; for 0.166667 h;Inert atmosphere;
Stage #2: with isopentyl nitrite for 0.166667 h;Inert atmosphere;
Stage #3: phenylboronic acidwith bis[(trifluoromethanesulfonyl)imidate]-2-(dicyclohexyl(2’,6’-dimethoxybiphenyl))phosphine gold(I);caesium carbonate in tetrahydrofuran at 20; for 3 h;Inert atmosphere;chemoselective reaction;Suzuki-Miyaura Coupling;

Steps:

3.31 4.3 4-Methoxybiphenyl (4a): representative procedure for the Au catalysed Suzuki-Miyaura couplings

General procedure: In a oven-dried flask and under nitrogen flow, benzenediazonium o-benzenedisulfonimide (1a, 161mg, 0.5mmol) was added to a suspension of 4-methoxyphenylboronic acid (3a, 91mg, 0.6mmol), [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I) (2:1) toluene adduct (39mg, 0.025mmol, 5mol%), Cs₂CO₃ (325mg, 1mmol) in THF (5mL). The resulting mixture was stirred at room temperature for 2h; the completion of the reaction was confirmed by the absence of azo coupling with 2-naphthol. Then, the reaction mixture was poured into diethyl ether/water (100mL, 1:1). The aqueous layer was separated and extracted with diethyl ether (50mL). The combined organic extracts were washed with water (50mL), dried with Na₂SO₄ and evaporated under reduced pressure. GC-MS analyses of the crude residue showed 4-methoxybiphenyl (4a), MS (EI): m/z 184 (M⁺) as the major product, besides traces of biphenyl, MS (EI): m/z 154 (M⁺), 4,4'-dimethoxybiphenyl, MS (EI): m/z 214 (M⁺), N-phenyl-o-benzenedisulfonimide, MS (EI): m/z 295 (M⁺). The crude residue was purified on a short column, eluting with petroleum ether/diethyl ether (9:1). The only isolated product was the title compound (4a, 81mg, 88% yield).

References:

Barbero, Margherita;Dughera, Stefano [Tetrahedron,2018,vol. 74,# 39,p. 5758 - 5769]

26137-08-6 Synthesis