3-PIPERIDIN-1-YLBENZONITRILE synthesis
- Product Name:3-PIPERIDIN-1-YLBENZONITRILE
- CAS Number:175696-74-9
- Molecular formula:C12H14N2
- Molecular Weight:186.25
Yield:175696-74-9 92%
Reaction Conditions:
Stage #1: 3-cyanobromobenzenewith TurboGrignard in tetrahydrofuran at 0; for 3 h;
Stage #2: N-chloropiperidinewith N,N,N,N,-tetramethylethylenediamine in tetrahydrofuran at -40 - 0;chemoselective reaction;
References:
Hatakeyama, Takuji;Yoshimoto, Yuya;Ghorai, Sujit K.;Nakamura, Masaharu [Organic Letters,2010,vol. 12,# 7,p. 1516 - 1519] Location in patent:supporting information; experimental part
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