3-(pyridin-2-ylamino)propanoic acid synthesis
- Product Name:3-(pyridin-2-ylamino)propanoic acid
- CAS Number:104961-64-0
- Molecular formula:C8H10N2O2
- Molecular Weight:166.18
504-29-0
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141-32-2
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104961-64-0
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$155.00/100mg
Yield: 57%
Reaction Conditions:
Stage #1:2-aminopyridine;acrylic acid n-butyl ester with acetic acid;potassium hydroxide at 70;
Stage #2: with water;potassium hydroxide at 25;
Steps:
41.1; 42.1 Step 1. 3 -(pyridin-2 -ylamino)propanoic acid
Into a 250-mL round-bottom flask, was placed pyridin-2 -amine (4 g, 42.50 mmol, 1.00 equiv), AcOH (752 mg, 12.52 mmol, 0.52 equiv), butyl prop-2-enoate (3.7 g, 28.87 mmol, 1.20 equiv). The resulting solution was stirred overnight at 70 oC. Potassium hydroxide (3.37 g, 60.06 mmol, 2.50 equiv), water (10 mL) was added. The resulting solution was stirred overnight at 25°C. The resulting mixture was concentrated under vacuum. The resulting mixture was washed with DCM (200 mL x 6). The solids were filtered out. The filtrate was concentrated to give 4 g (57%) of 3 -(pyridin-2 -ylamino)propanoic acid as brown oil. MS (ES, m/z) [M+H]+: 167.
References:
THE ROCKEFELLER UNIVERSITY;PONDA, Manish P.;SELNICK, Harold;EGBERTSON, Melissa;BRESLOW, Jan L. WO2019/108565, 2019, A1 Location in patent:Paragraph 0274; 0275
55364-85-7
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104961-64-0
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$155.00/100mg
504-29-0
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$5.00/5 g
79-10-7
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104961-64-0
52 suppliers
$155.00/100mg
504-29-0
556 suppliers
$5.00/5 g
104961-64-0
52 suppliers
$155.00/100mg
50342-32-0
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104961-64-0
52 suppliers
$155.00/100mg