3-Thiophenezoic acid synthesis
- Product Name:3-Thiophenezoic acid
- CAS Number:88-13-1
- Molecular formula:C5H4O2S
- Molecular Weight:128.15
498-62-4
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88-13-1
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Yield:88-13-1 80%
Reaction Conditions:
with chromic acid in diethyl ether at 0; for 3 h;
Steps:
2.3 3, The preparation of 3-thiophene carboxylic acid
The reaction temperature was zero, the reaction time was 3h, the yield was about 80%.
In a 1 L two-necked flask, 24.5 g of 3-methylthiophene (98 g mol-1,24.5 g, 250 mmol) was added and 400 mL of chloroform / glacial acetic acid (V: V = 1: / L,Favoring the inhibition of the bis-brominated product), 44.5 g of NBS (178 g mol-1, 44.5 g, 250 mmol) were added in portions in an ice-water bath.After the addition of NBS to continue stirring for 2-3 hours, TLC monitoring. After treatment: deionized water to quench the reaction, liquid separation, the organic phase was NaOH solution, washed with water, dried, concentrated vacuum pump with fractional distillation.
References:
Wuhan University of Technology;Xiao Shengqiang;Chen Run;You Wei;Zhan Chun CN106588868, 2017, A Location in patent:Paragraph 0025-0029; 0043; 0050-0052
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88-13-1
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