3-(Trifluoromethoxy)phenylisothiocyanate synthesis
- Product Name:3-(Trifluoromethoxy)phenylisothiocyanate
- CAS Number:471937-78-7
- Molecular formula:C8H4F3NOS
- Molecular Weight:219.18
6160-65-2
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$6.00/1g
1535-73-5
268 suppliers
$9.00/5g
471937-78-7
21 suppliers
$45.00/100mg
Yield:471937-78-7 50%
Reaction Conditions:
in DMF (N,N-dimethyl-formamide) at 0 - 20; for 1.5 h;
Steps:
IV
[0147] A solution of 3.46 g (19.5 mM) of 3-(trifluoromethoxy)aniline in 150 ml of dimethylformamide is prepared and is cooled to 0° C. A solution of 3.83 g (21.45 mM) of thiocarbonyldiimidazole dissolved in 60 ml of dimethylformamide is then added dropwise. The reaction mixture is agitated at ordinary temperature for 1 hour 30 minutes, then poured onto 300 ml of water, and extracted with twice 100 ml of ethyl ether. These organic phases are washed with twice 50 ml of water, dried over magnesium sulphate and then concentrated under reduced pressure. This residue is purified by chromatography on silica gel in eluting with the aid of a cyclohexane/ethyl acetate mixture (95/5; v/v). 2.1 g of product sought after are thus obtained as a green-yellow liquid (yield=50%). [0148] 1H NMR (CDCl3, 300 MHz): 7.38 (t, 1H); 7.15 (m, 3H)
References:
US2004/116417,2004,A1 Location in patent:Page/Page column 7
463-71-8
152 suppliers
$32.00/10g
1535-73-5
268 suppliers
$9.00/5g
471937-78-7
21 suppliers
$45.00/100mg