ChemicalBook CAS DataBase List Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate

Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate synthesis

11synthesis methods

Product Name:Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate
CAS Number:342417-02-1
Molecular formula:C19H24N4O2
Molecular Weight:340.42

342417-01-0 Synthesis

3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-

342417-01-0
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124-41-4 Synthesis

124-41-4
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$12.00/25g

Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate

342417-02-1
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Yield:342417-02-1 100%

Reaction Conditions:

Stage #1: sodium methylatewith N-Bromosuccinimide in methanol;dichloromethane at -5; for 16 h;
Stage #2: 4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide in methanol;dichloromethane at -5; for 5.3 h;

Steps:

1.5 Synthesis of methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine

Step 5
2.15 ml (11.6 mMol) Sodium methoxide in methanol were added over 30 minutes to a suspension of 0.85 g (4.6 mMol) N-bromosuccinimide in 5.0 ml dichloromethane cooled to -5° C.
The reaction mixture was stirred 16 hours at -5° C.
Still at this temperature, a solution of 1.0 g (3.1 mMol) 6-(4-methyl-piperazin-1-yl)-4-o-tolyl-nicotinamide in 5.0 ml methanol was added over 20 minutes and stirred for 5 hours. 7.1 ml (7.1 mMol) Aqueous HCl 1N and 20 ml dichloromethane were added.
The phases were separated and the organic phase was washed with deionized water.
The aqueous phases were extracted with dichloromethane, brought to pH=8 with aqueous NaOH 1N and further extracted with dichloromethane.
The latter organic extracts were combined, dried (Na₂SO₄) and concentrated to yield 1.08 g (quant.) [6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-carbamic acid methyl ester as a grey foam. MS (ISP): 341 (M+H⁺, 100), 284 (35).

References:

US8426450,2013,B1 Location in patent:Page/Page column 26

5326-23-8 Synthesis