3-AMINO-4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:3-AMINO-4-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
- CAS Number:35212-88-5
- Molecular formula:C11H11NO3S
- Molecular Weight:237.27
94088-46-7
188 suppliers
$16.00/25g
2365-48-2
369 suppliers
$14.00/25g
35212-88-5
29 suppliers
$75.00/250mg
Yield:35212-88-5 83%
Reaction Conditions:
with NaH in dimethyl sulfoxide;
Steps:
18 4-(3-Bromoanilino)-9-methoxybenzo[b]thieno[3,2-d]pyrimidine hydrochloride.
Methyl 3-amino-4-methoxybenzothiophene-2-carboxylate. Methyl thioglycollate (0.18 mL, 1.9 mmol) is added dropwise to a suspension of NaH (60% oil suspension, 176 mg, 4.4 mmol) in DMSO (5 mL), stirred under N2 at 25° C. When gas evolution ceases, 2-fluoro-6-methoxybenzonitrile (266 mg, 1.76 mmol) in DMSO 5 mL is added in one portion. After 3 h, the reaction mixture is poured onto ice-water, and the beige precipitate is collected by suction filtration, rinsed and air dried to give methyl 3-amino-4-methoxybenzothiophene-2-carboxylate (345 mg, 83%). 1 H NMR (DMSO) δ7.44-7.37 (2H, m), 7.00, (2H brs), 6.90 (1H, d, J=7.7Hz), 3.95 (3H, s), 3.76 (3H, s).
References:
US5679683,1997,A
886362-07-8
58 suppliers
$32.00/1g
2365-48-2
369 suppliers
$14.00/25g
35212-88-5
29 suppliers
$75.00/250mg
146137-74-8
197 suppliers
$6.00/250mg
35212-88-5
29 suppliers
$75.00/250mg
456-49-5
376 suppliers
$8.00/10g
35212-88-5
29 suppliers
$75.00/250mg
171179-83-2
1 suppliers
inquiry
35212-88-5
29 suppliers
$75.00/250mg