Methyl 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate synthesis
- Product Name:Methyl 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate
- CAS Number:354793-04-7
- Molecular formula:C10H8N2O4
- Molecular Weight:220.18
36692-49-6
95-92-1
354793-04-7
The condensation reaction was carried out by reacting methyl 3,4-diaminobenzoate and diethyl oxalate (8.0 eq.) in toluene (10 v/v) under reflux conditions for 88 hours. After the reaction was complete, the reaction mixture was concentrated to dryness and the resulting residue was washed with methyl tert-butyl ether (MTBE). After drying, Intermediate 184 was obtained in 90% yield.
36692-49-6
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95-92-1
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354793-04-7
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Yield:354793-04-7 90%
Reaction Conditions:
in toluene; for 88 h;Reflux;
Steps:
A44 Preparation of intermediate 184:
Condensation of methyl 3 ,4-diaminobenzoate with diethyl oxalate (8.0 equivalents) in toluene (10 volumes) was carried out at reflux for 88 hours. After complete conversion, the mixture was concentrated to a residue which was washed with MTBE. After drying intermediate 184 was obtained in 90% yield.
References:
WO2017/60406,2017,A1 Location in patent:Page/Page column 172