4-(1,3-benzoxazol-2-yl)-N,N-dimethylaniline synthesis
- Product Name:4-(1,3-benzoxazol-2-yl)-N,N-dimethylaniline
- CAS Number:840-57-3
- Molecular formula:C15H14N2O
- Molecular Weight:238.28
Yield:840-57-3 92%
Reaction Conditions:
with potassium cyanide in N,N-dimethyl-formamide; for 0.0666667 h;Microwave irradiation;
Steps:
Typical Procedure for the Synthesis of Benzoxazoles from Arylaldehydes
General procedure: A mixture of 2-aminophenol (0.13 g, 1.1 mmol), substitutedbenzaldehydes (2.2 mmol), and potassium cyanide (1.1 mmol)in 4 mL N,N-dimethylformamide was irradiated in a microwave oven at 450 W. The progress of the reaction was monitored using thin-layer chromatography (petroleum ether/ethylacetate, 6/2). After the completion of the reaction, the mixturewas cooled and extracted with ethyl acetate (3￡10 mL) andthe organic layer was concentrated under reduced pressure.Then, recrystallization of the crude product was carried out in aboiling mixture of ethanol/water (1:1) to give the pure product.
References:
Naeimi, Hossein;Rahmatinejad, Soraya [Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry,2016,vol. 46,# 3,p. 471 - 476]
