4-(1H-1,2,4-TRIAZOL-1-YL)BENZALDEHYDE synthesis
- Product Name:4-(1H-1,2,4-TRIAZOL-1-YL)BENZALDEHYDE
- CAS Number:27996-86-7
- Molecular formula:C9H7N3O
- Molecular Weight:173.17
288-88-0
459-57-4
27996-86-7
GENERAL METHOD: A mixture of 4-fluorobenzaldehyde (10 mmol) and 1,2,4-triazole (10 mmol) was dissolved in anhydrous N,N-dimethylformamide (DMF, 20 mL). Potassium carbonate (K2CO3, 12 mmol) was added to the above stirred solution in portions over 15 minutes. The reaction mixture was stirred at 110°C for 10-12 hours. After completion of the reaction, the heating was stopped and the potassium carbonate was removed by filtration. The filtrate was extracted with ethyl acetate (3 x 15 mL). The organic layers were combined, washed with water (3 x 15 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (60-120 mesh) with the eluent of methanol:chloroform (1:99, v/v) to obtain the target compound 4-(1-1,2,4-triazolyl)benzaldehyde.
451-46-7
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$5.00/5g
27996-86-7
130 suppliers
$9.00/1g
Yield:-
Steps:
Multi-step reaction with 3 steps
1: 48 percent / NaH / dimethylsulfoxide / 18 h / 100 °C
2: 77 percent / NaBH4, CaCl2 / tetrahydrofuran / Ambient temperature
3: 49 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 1.5 h / Ambient temperature
References:
Artico;Silvestri;Stefancich;Avigliano;Di Giulio;Maccarrone;Agostinelli;Mondovi;Morpurgo [European Journal of Medicinal Chemistry,1992,vol. 27,# 3,p. 219 - 228]
![[4-(1H-1,2,4-Triazol-1-yl)phenyl]methanol](/CAS/GIF/143426-50-0.gif)
143426-50-0
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$30.00/1g
27996-86-7
130 suppliers
$9.00/1g
288-32-4
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$5.00/25g
459-57-4
604 suppliers
$6.00/25g
27996-86-7
130 suppliers
$9.00/1g