4-[(3-CHLOROBENZYL)OXY]BENZENECARBALDEHYDE synthesis
- Product Name:4-[(3-CHLOROBENZYL)OXY]BENZENECARBALDEHYDE
- CAS Number:59067-43-5
- Molecular formula:C14H11ClO2
- Molecular Weight:246.69
123-08-0
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766-80-3
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59067-43-5
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Yield:59067-43-5 96.6%
Reaction Conditions:
with potassium carbonate;potassium iodide in acetone at 70; for 2 h;
Steps:
3 4-(3-Chloro-benzyloxy)-benzaldehyde
Example 3 4-(3-Chloro-benzyloxy)-benzaldehyde A 0.5 M solution of 1-bromomethyl-3-chloro-benzene (102.7 mg, 0.5 mmol) in acetone was added to a suspension of 4-hydroxy-benzaldheyde (67.2 mg, 0.55 mmol), K2CO3 (207.3 mg, 1.5 mmol) and KI (10.8 mg, 0.065 mmol) in acetone (7 ml). The reaction mixture was stirred for 2 hours at 70°C. After cooling, the solid residue was filtered off and the solvent was evaporated under vacuum. The residue was dissolved in ethyl acetate and the organic layer washed twice with 1 M NaOH and dried over Na2SO4. The title compound was obtained (85 mg) after evaporating the solvent under vacuum, yielding 96.6%.
References:
EP1524267,2005,A1 Location in patent:Page/Page column 13
123-08-0
885 suppliers
$5.00/10g
620-20-2
312 suppliers
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59067-43-5
28 suppliers
$57.50/250mg
64-17-5
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123-08-0
885 suppliers
$5.00/10g
620-20-2
312 suppliers
$5.00/25g
59067-43-5
28 suppliers
$57.50/250mg