4-(3-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE synthesis
- Product Name:4-(3-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE
- CAS Number:63843-53-8
- Molecular formula:C11H15Cl2NO
- Molecular Weight:248.15
Yield:63843-53-8 83.2%
Reaction Conditions:
Stage #1: 4-HYDROXYPIPERIDINEwith potassium tert-butylate in 1-methyl-pyrrolidin-2-one at 65; for 0.5 h;Inert atmosphere;Large scale;
Stage #2: 1-Chloro-4-fluorobenzene in 1-methyl-pyrrolidin-2-one at 65 - 75; for 4 h;Inert atmosphere;Large scale;
References:
Frutos, Rogelio P.;Tampone, Thomas G.;Mulder, Jason A.;Rodriguez, Sonia;Yee, Nathan K.;Yang, Bing-Shiou;Senanayake, Chris H. [Organic Process Research and Development,2016,vol. 20,# 5,p. 982 - 988]
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63843-53-8
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