4,4'-(1,4-piperazinediyl)bis-Benzaldehyde synthesis

Yield: 93%

Reaction Conditions:

in 2-methoxy-ethanol;water for 12 h;Reflux;

Steps:

1.2 (2) Synthesis of 4,4 ’-(piperazine-1,4-diyl) benzaldehyde (Compound 2):
Piperazine (1.0 g, 11.62 mmol) was dissolved in H2O (18 mL) and 2-methoxyethanol (20 mL).The mixture was heated to reflux, and then a solution of 4-fluorobenzaldehyde (0.63 mL, 5.81 mmol) dissolved in 2-methoxyethanol (5 mL) was added.Then the mixture continued to reflux for 12 hours. After cooling to room temperature,The mixture was poured into H2O (50 mL) and a light yellow precipitate was obtained. The precipitate was filtered and dried to obtain a yellow solid 2 with a yield of 93%.

References:

University of Jinan;Lin Weiying;Guo Dingyi;Tian Minggang;Sun Jie CN110776458, 2020, A Location in patent:Paragraph 0019; 0020