4-(4-CHLOROBUTYL) PYRIDINE synthesis
- Product Name:4-(4-CHLOROBUTYL) PYRIDINE
- CAS Number:5264-17-5
- Molecular formula:C9H12ClN
- Molecular Weight:169.65
108-89-4
319 suppliers
$15.00/25mL
109-70-6
473 suppliers
$10.00/5g
5264-17-5
32 suppliers
$196.02/250mg
Yield: 97.6%
Reaction Conditions:
with n-butyllithium in tetrahydrofuran;water
Steps:
10.i (i)
(i) 4-(4-Chlorobutyl)pyridine 4-Methylpyridine (8.4 g, 90 mmol) and THF (40 mL) were mixed in dry glassware, flushed with nitrogen and cooled to -60° C. n-BuLi (1.6 M solution, 61.9 mL, 99 mmol) was added dropwise over 1.5 h. The temperature was not allowed to exceed -50° C. The mixture was then allowed to reach rt, THF (20 mL) was added and the mixture was then stirred at 45° C. for 2 h. Additional THF (20 mL) was added. This mixture was cooled to 0° C. and added dropwise through a cooled dropping funnel to a 65° C. solution of 3-bromo-1-chloropropane (14.9 g, 94.5 mmol) in THF (15 mL). The reaction mixture was slowly allowed to reach 0° C. overnight. Water (90 mL) was added, and the mixture was stirred for 10 min. The organic layer was separated and dried (Na2SO4) to give the sub-title compound in 97.6% yield.
References:
5264-15-3
128 suppliers
$9.00/100mg
5264-17-5
32 suppliers
$196.02/250mg
108-89-4
319 suppliers
$15.00/25mL
5264-17-5
32 suppliers
$196.02/250mg
102878-73-9
47 suppliers
$260.00/500mg
5264-17-5
32 suppliers
$196.02/250mg
100-43-6
146 suppliers
$22.19/5ml
5264-17-5
32 suppliers
$196.02/250mg