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ChemicalBook CAS DataBase List 4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL
216690-19-6

4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL synthesis

1synthesis methods
3-Piperidinecarboxylic acid, 4-(4-fluorophenyl)-2,6-dioxo-, ethyl ester

391937-08-9
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4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL

216690-19-6
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Yield:216690-19-6 22%

Reaction Conditions:

in tetrahydrofuran;

Steps:

6 (+-)-trans-4-(4'-Fluorophenyl)-3-hydroxymethylpiperidine

EXAMPLE 6 (+-)-trans-4-(4'-Fluorophenyl)-3-hydroxymethylpiperidine Compound E1 (+-)-trans-3-ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione (2.0 g) was reduced with lithium aluminium hydride (0.58 g) in refluxing tetrahydrofuran (50 ml) for 4 hours. Work up as described in Example 5 gave the title compound as a solid (0.28 g, 22%).

References:

US4902801,1990,A

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