4-(4-METHOXYPHENOXY)BENZALDEHYDE 97 synthesis
- Product Name:4-(4-METHOXYPHENOXY)BENZALDEHYDE 97
- CAS Number:78725-47-0
- Molecular formula:C14H12O3
- Molecular Weight:228.24
555-16-8
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150-76-5
800 suppliers
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78725-47-0
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$45.00/100mg
Yield:78725-47-0 97%
Reaction Conditions:
with copper(II) acetate monohydrate;caesium carbonate in N,N-dimethyl-formamide at 100; for 4 h;Inert atmosphere;Schlenk technique;
Steps:
4.2 General procedure for the synthesis of unsymmetrical diaryl ethers
General procedure: Under N2 atmosphere, a Schlenk tube was charged with nitroarenes 1 (0.5 mmol), phenols 2 (1.0 mmol), Cu(OAc)2·H2O (5 mol %), and Cs2CO3 (1.0 mmol) in DMF (3 mL) at room temperature. After that, the mixture was stirred constantly at 100 °C (oil bath temperature) for 4 h. After the completion of the reaction, as monitored by TLC and GC-MS analysis, the reaction mixture was cooled to room temperature, diluted with ethyl acetate, and filtrated. The filtrate was concentrated under vacuum, and the resulting residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate) to afford the desired arylated product 3.
References:
Chen, Jiuxi;Wang, Xingyong;Zheng, Xingwang;Ding, Jinchang;Liu, Miaochang;Wu, Huayue [Tetrahedron,2012,vol. 68,# 43,p. 8905 - 8907] Location in patent:supporting information
459-57-4
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150-76-5
800 suppliers
$5.00/5G
78725-47-0
49 suppliers
$45.00/100mg
1122-91-4
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$9.00/10g
150-76-5
800 suppliers
$5.00/5G
78725-47-0
49 suppliers
$45.00/100mg
5720-07-0
472 suppliers
$6.00/5g
555-16-8
563 suppliers
$5.00/5g
78725-47-0
49 suppliers
$45.00/100mg
5720-07-0
472 suppliers
$6.00/5g
123-08-0
951 suppliers
$5.00/10g
78725-47-0
49 suppliers
$45.00/100mg