4-(4-methylphenoxy)-Benzenemethanamine synthesis
- Product Name:4-(4-methylphenoxy)-Benzenemethanamine
- CAS Number:129560-03-8
- Molecular formula:C14H15NO
- Molecular Weight:213.27
37563-42-1
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129560-03-8
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Yield:129560-03-8 96.1%
Reaction Conditions:
with ammonia;hydrogen in methanol at 55; under 26252.6 Torr; for 3 h;Inert atmosphere;Large scale;Reagent/catalyst;Solvent;
Steps:
1; 4
Add 200kg of methanol solution of ammonia to the 500L autoclave (mass fraction of NH3 is 8%),4-(4'-methylphenoxy)benzonitrile 50kg,Replace with nitrogen three times,Then add 2.5kg of Raney nickel catalyst,Seal the system, turn on the stirring, replace with hydrogen three times,Warm up to 55°C,The hydrogen gas pressure reaches 3.5Mpa, the heat preservation reaction is 3h,Sampling and testing, the remaining raw material is less than 0.2%,4-(4’-methylphenoxy)benzylamine is over 98%, the yield is 96.1%,
References:
CN113024389,2021,A Location in patent:Paragraph 0028-0029; 0032
1706-12-3
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75-05-8
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129560-03-8
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1194-02-1
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623-03-0
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129560-03-8
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