ChemicalBook CAS DataBase List 4-(4-methylphenoxy)-Benzenemethanamine

4-(4-methylphenoxy)-Benzenemethanamine synthesis

6synthesis methods

Product Name:4-(4-methylphenoxy)-Benzenemethanamine
CAS Number:129560-03-8
Molecular formula:C14H15NO
Molecular Weight:213.27

37563-42-1
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129560-03-8
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Yield:129560-03-8 96.1%

Reaction Conditions:

with ammonia;hydrogen in methanol at 55; under 26252.6 Torr; for 3 h;Inert atmosphere;Large scale;Reagent/catalyst;Solvent;

Steps:

1; 4

Add 200kg of methanol solution of ammonia to the 500L autoclave (mass fraction of NH3 is 8%),4-(4'-methylphenoxy)benzonitrile 50kg,Replace with nitrogen three times,Then add 2.5kg of Raney nickel catalyst,Seal the system, turn on the stirring, replace with hydrogen three times,Warm up to 55°C,The hydrogen gas pressure reaches 3.5Mpa, the heat preservation reaction is 3h,Sampling and testing, the remaining raw material is less than 0.2%,4-(4’-methylphenoxy)benzylamine is over 98%, the yield is 96.1%,

References:

CN113024389,2021,A Location in patent:Paragraph 0028-0029; 0032