4-(4-Piperidinyloxy)benzoic acid ethyl ester HCl synthesis
- Product Name:4-(4-Piperidinyloxy)benzoic acid ethyl ester HCl
- CAS Number:950649-15-7
- Molecular formula:C14H20ClNO3
- Molecular Weight:285.77
210962-44-0
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950649-15-7
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Yield:950649-15-7 93%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20; for 2 h;
Steps:
61.B
Step C: 4-(4-CarboxyethylphenyloxyVpiperidine-l-carboxylic acid 2.4- dichloro-benzylamideTo the compound from Step B (8.27 g, 28.9 mmol) and diisopropylethylamine (10.1 mL, 58.0 mmol) in acetonitrile (100 mL) is added 2,4-dichloro- 1 -isocyanatomethyl- benzene (4.25 mL, 29.2 mmol). The mixture is stirred at rt for 16 h, evaporated in vacuo, dissolved in ethyl acetate, washed repeatedly with water, evaporated in vacuo and triturated with hexane/ethyl acetate to give the desired compound (13.1 g, 99%).
References:
WO2007/106705,2007,A1 Location in patent:Page/Page column 115
120-47-8
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950649-15-7
19 suppliers
$300.00/500mg