ChemicalBook
Chinese Japanese Germany Korea

Ethylparaben

Ethylparaben
Ethylparaben structure
CAS No.
120-47-8
Chemical Name:
Ethylparaben
Synonyms
Ethyl;Sobrol A;nipazina;solbrola;Of ethyl;Solbro A;Easeptol;Keloform;Mycocten;napagina
CBNumber:
CB5119772
Molecular Formula:
C9H10O3
Formula Weight:
166.17
MOL File:
120-47-8.mol

Ethylparaben Properties

Melting point:
114-117 °C (lit.)
Boiling point:
297-298 °C (lit.)
Density 
1.1708 (rough estimate)
vapor pressure 
0.00012 hPa (25 °C)
refractive index 
1.5286 (estimate)
Flash point:
297-298°C
storage temp. 
2-8°C
solubility 
Very slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
form 
Crystalline Powder
pka
8.31±0.13(Predicted)
color 
White
PH
4.5-5.5 (H2O, 20°C) (saturated solution)
Water Solubility 
Slightly soluble in water.
Merck 
14,3837
BRN 
1101972
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference
120-47-8(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances
ETHYLPARABEN
FDA 21 CFR
175.105; 175.300
EWG's Food Scores
3-4
FDA UNII
14255EXE39
NIST Chemistry Reference
Ethylparaben(120-47-8)
ATC code
D01AE10
EPA Substance Registry System
Ethylparaben (120-47-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H303-H315-H317-H319
Precautionary statements  P261-P264-P272-P280-P302+P352+P333+P313+P363-P305+P351+P338+P337+P313-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  1
RTECS  DH2190000
Autoignition Temperature 495 °C
TSCA  Yes
HS Code  29182930
Toxicity LD50 orally in Rabbit: > 2000 mg/kg

Ethylparaben price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 111988 Ethyl 4-hydroxybenzoate ReagentPlus , 99% 120-47-8 5g $16.8 2020-08-18 Buy
Sigma-Aldrich 111988 Ethyl 4-hydroxybenzoate ReagentPlus , 99% 120-47-8 100g $28.7 2020-08-18 Buy
Sigma-Aldrich E2425000 Ethyl parahydroxybenzoate European Pharmacopoeia (EP) Reference Standard 120-47-8 $190 2021-03-22 Buy
Sigma-Aldrich 1.00887 Ethyl 4-hydroxybenzoate EMPROVE? ESSENTIAL Ph Eur,BP,JP,NF 120-47-8 5 kg $388 2021-03-22 Buy
Sigma-Aldrich 1.00887 Ethyl 4-hydroxybenzoate EMPROVE? ESSENTIAL Ph Eur,BP,JP,NF 120-47-8 25 kg $1290 2021-03-22 Buy

Ethylparaben Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Chemical Properties

Ethylparaben occurs as a white, odorless or almost odorless, crystalline powder.

Uses

An antimicrobial

Uses

bronchodilator, tocolytic

Uses

Preservative for pharmaceuticals.

Production Methods

Ethylparaben is prepared by the esterification of p-hydroxybenzoic acid with ethanol (95%).

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3343, 1974 DOI: 10.1021/jo00937a007

Pharmaceutical Applications

Ethylparaben is widely used as an antimicrobial preservative in cosmetics,food products, and pharmaceutical formulations.
It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics it is one of the most frequently used preservatives.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used. However, this may cause the pH of poorly buffered formulations to become more alkaline.

Contact allergens

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Safety

Ethylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations.
Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. Parabens, in vivo, have also been reported to exhibit estrogenic responses in fish.(10) The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg body-weight.
LD50 (mouse, IP): 0.52 g/kg
LD50 (mouse, oral): 3.0 g/kg

storage

Aqueous ethylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).
Ethylparaben should be stored in a well-closed container in a cool, dry place.

Incompatibilities

The antimicrobial properties of ethylparaben are considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of ethylparaben by plastics has not been reported, although it appears probable given the behavior of other parabens. Ethylparaben is coabsorbed on silica in the presence of ethoxylated phenols. Yellow iron oxide, ultramarine blue, and aluminum silicate extensively absorb ethylparaben in simple aqueous systems, thus reducing preservative efficacy.
Ethylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

Regulatory Status

Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Ethylparaben Preparation Products And Raw materials

Raw materials

Preparation Products


Ethylparaben Suppliers

Global( 549)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20898 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880623
022-66880086 sales@tjzxchem.com CHINA 537 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58

View Lastest Price from Ethylparaben manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-07 Ethylparaben
120-47-8
US $20.00 / Kg/Drum 25Kg/Drum 99.99% 1 ton per week Wuhan Mulei New Material Technology Co. Ltd
2021-12-07 Ethylparaben
120-47-8
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-12-01 Ethylparaben
120-47-8
US $8.70 / Kg/Drum 10g 99.5% min 10000kg Hebei Crovell Biotech Co Ltd

Ethylparaben Spectrum


120-47-8(Ethylparaben)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved