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Ethylparaben

Ethylparaben
Ethylparaben structure
CAS No.
120-47-8
Chemical Name:
Ethylparaben
Synonyms
Ethyl;Sobrol A;nipazina;solbrola;Of ethyl;Solbro A;Easeptol;Keloform;Mycocten;napagina
CBNumber:
CB5119772
Molecular Formula:
C9H10O3
Formula Weight:
166.17
MOL File:
120-47-8.mol

Ethylparaben Properties

Melting point:
114-117 °C(lit.)
Boiling point:
297-298 °C(lit.)
Density 
1.1708 (rough estimate)
vapor pressure 
0.00012 hPa (25 °C)
refractive index 
1.5286 (estimate)
Flash point:
297-298°C
storage temp. 
0-6°C
solubility 
Very slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
form 
Crystalline Powder
color 
White
PH
4.5-5.5 (H2O, 20°C) (saturated solution)
Water Solubility 
Slightly soluble in water.
Merck 
14,3837
BRN 
1101972
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference
120-47-8(CAS DataBase Reference)
NIST Chemistry Reference
Ethylparaben(120-47-8)
EPA Substance Registry System
Benzoic acid, 4-hydroxy-, ethyl ester(120-47-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  1
RTECS  DH2190000
Autoignition Temperature 495 °C
TSCA  Yes
HS Code  29182930
Hazardous Substances Data 120-47-8(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 2000 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P501 Dispose of contents/container to..…

Ethylparaben price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 111988 Ethyl 4-hydroxybenzoate ReagentPlus , 99% 120-47-8 5g $16.2 2018-11-13 Buy
Sigma-Aldrich 111988 Ethyl 4-hydroxybenzoate ReagentPlus , 99% 120-47-8 100g $27.7 2018-11-13 Buy
TCI Chemical E0884 Ethyl 4-Hydroxybenzoate [for Biochemical Research] >99.0%(GC)(T) 120-47-8 5g $25 2018-11-22 Buy
TCI Chemical E0884 Ethyl 4-Hydroxybenzoate [for Biochemical Research] >99.0%(GC)(T) 120-47-8 25g $49 2018-11-22 Buy
Alfa Aesar A13172 Ethyl 4-hydroxybenzoate, 99% 120-47-8 250g $32.1 2018-11-13 Buy

Ethylparaben Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Chemical Properties

Ethylparaben occurs as a white, odorless or almost odorless, crystalline powder.

Uses

An antimicrobial

Uses

bronchodilator, tocolytic

Uses

Preservative for pharmaceuticals.

Production Methods

Ethylparaben is prepared by the esterification of p-hydroxybenzoic acid with ethanol (95%).

Pharmaceutical Applications

Ethylparaben is widely used as an antimicrobial preservative in cosmetics,food products, and pharmaceutical formulations.
It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics it is one of the most frequently used preservatives.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used. However, this may cause the pH of poorly buffered formulations to become more alkaline.

Contact allergens

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Safety

Ethylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations.
Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. Parabens, in vivo, have also been reported to exhibit estrogenic responses in fish.(10) The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg body-weight.
LD50 (mouse, IP): 0.52 g/kg
LD50 (mouse, oral): 3.0 g/kg

storage

Aqueous ethylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).
Ethylparaben should be stored in a well-closed container in a cool, dry place.

Incompatibilities

The antimicrobial properties of ethylparaben are considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of ethylparaben by plastics has not been reported, although it appears probable given the behavior of other parabens. Ethylparaben is coabsorbed on silica in the presence of ethoxylated phenols. Yellow iron oxide, ultramarine blue, and aluminum silicate extensively absorb ethylparaben in simple aqueous systems, thus reducing preservative efficacy.
Ethylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

Regulatory Status

Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Ethylparaben Preparation Products And Raw materials

Raw materials

Preparation Products


Ethylparaben Suppliers

Global( 366)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19954 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 500 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1662 55
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2238 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58

View Lastest Price from Ethylparaben manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Ethylparaben
120-47-8
US $1.00 / KG 1G 98% 100KG career henan chemical co

Ethylparaben Spectrum


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