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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 4,5-Dichloro-2-octyl-isothiazolone
64359-81-5

4,5-Dichloro-2-octyl-isothiazolone synthesis

3synthesis methods
Add 200 g of ethyl acetate and 23.6 g (0.1 mol) of N,N'-dimethyl-3,3'-dithiodipropionamide into a 500ml four-neck flask equipped with a thermometer and a stirrer, stir and mix, and control The reaction temperature was 15° C., 1.8 g of thionyl chloride (15.1 mmol) was added to the four-neck flask, and the mixture was stirred for 10 min.21.3g (0.3mol) of chlorine gas was introduced into the reaction system, the mixture was stirred for 5h to react, and 27.1g of 4,5-Dichloro-2-octyl-isothiazolone was obtained by filtration and separation. The yield was 84.9%.
33312-01-5 Synthesis
3,3'-Dithiobis(N-octylpropionamide)

33312-01-5
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4,5-Dichloro-2-octyl-isothiazolone

64359-81-5
278 suppliers
$6.00/1g

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Yield:64359-81-5 91%

Reaction Conditions:

with trichlorophosphate in acetic acid butyl ester at 10 - 40; for 2 h;Temperature;

Steps:

1-4

Add 200 mL of butyl acetate into a round bottom flask with an exhaust gas absorption device, then add the above intermediate 3,3'-dithiodioctylpropionamide, and slowly drop 100 g of phosphorus oxychloride at 10°C. After the dripping is completed and the gas no longer comes out, the ice bath is removed, and the temperature is raised to 40° C. to continue the reaction for 2 hours. After the reaction, the reactor was cooled to 5°C, and 5% sodium bicarbonate solution was slowly dropped to neutrality. After separating the water layer, the solvent was dried off and recrystallized with methanol to obtain a white solid.It is 4,5-dichloro-2-n-octyl-3-isothiazolinone, the solid weight is 94.55g, the yield is 91%,

References:

CN113582941,2021,A Location in patent:Paragraph 0032-0033; 0035; 0036; 0038; 0039; 0041; 0042; ...

26530-20-1 Synthesis
2-Octyl-2H-isothiazol-3-one

26530-20-1
299 suppliers
$38.00/1g

4,5-Dichloro-2-octyl-isothiazolone

64359-81-5
278 suppliers
$6.00/1g

References
33312-01-5 Synthesis
3,3'-Dithiobis(N-octylpropionamide)

33312-01-5
32 suppliers
inquiry

4,5-Dichloro-2-octyl-isothiazolone

64359-81-5
278 suppliers
$6.00/1g

26530-20-1 Synthesis
2-Octyl-2H-isothiazol-3-one

26530-20-1
299 suppliers
$38.00/1g

References

4,5-Dichloro-2-octyl-isothiazolone Related Search:

2-Octyl-2H-isothiazol-3-one 2-Methyl-4-isothiazolin-3-one Dichloroacetonitrile 2-Methyl-4-isothiazolin-3-one hydrochloride thiazol-3-one Thiazole Isothiazole 5-Chloro-2-methyl-4-isothiazolin-3-one