4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZOIC ACID synthesis
- Product Name:4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZOIC ACID
- CAS Number:95124-68-8
- Molecular formula:C10H8N2O3
- Molecular Weight:204.18
81386-30-3
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$23.10/250mg
95124-68-8
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$30.00/250mg
Yield:95124-68-8 94%
Reaction Conditions:
with basic cobalt(II) carbonate;sodium bromide in acetic acid at 95; for 11 h;Catalytic behavior;Green chemistry;Reagent/catalyst;Temperature;
Steps:
Oxidation of 4 and 3 methyl-5-R-1,2,4-oxadiazoles (general procedure).
General procedure: Oxidation process was carried out in an ideal mixing reactor. A starting methylarene 1a-h (13 mmol), cobalt acetate (1.3 mmol), and sodium bromide (1.3 mmol) were dissolved in glacial acetic acid (40 mL). Then, the solution was heated to 95 °C and air was fed to the reactor. The reaction mixture was allowed to stand for 11 h at 95 °C and cooled to ~20 °C, a precipitate formed was filtered. 4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoic acid (2a). The yield was 94%, m.p. 225-226 C. IR, ν/cm-1: 2670 (OH); 1686 (C=O); 1594 (Ar); 1289 (C-O). MS (70 eV), m/z (I rel (%)): 204 [M]+ (78),187 (3), 163 (100), 146 (31), 118 (14), 102 (5), 90 (9), 88 (9). 1H NMR, δ: 2.70 (s, 3 H, Me); 8.11 (s, 4 H, Ar); 13.26 (br.s, 1 H). 13C NMR, δ: 11.91, 126.99, 129.98, 133.10, 166.51, 166.92, 177.68.
References:
Krasouskaya;Danilova;Baikov;Kolobov;Kofanov [Russian Chemical Bulletin,2015,vol. 64,# 1,p. 142 - 145][Izv. Akad. Nauk, Ser. Khim.,2015,# 1,p. 142 - 145,4]
196301-94-7
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$90.00/100mg
95124-68-8
79 suppliers
$30.00/250mg
1129-35-7
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$8.00/5g
95124-68-8
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$30.00/250mg
![METHYL 4-[(Z)-AMINO(HYDROXYIMINO)METHYL]BENZOATE](/CAS/GIF/65695-05-8.gif)
65695-05-8
68 suppliers
$34.00/250mg
95124-68-8
79 suppliers
$30.00/250mg
65695-05-8
68 suppliers
$34.00/250mg
95124-68-8
79 suppliers
$30.00/250mg