4,6-Dichloro-3-pyridazinecarboxylic acid synthesis
- Product Name:4,6-Dichloro-3-pyridazinecarboxylic acid
- CAS Number:1040246-87-4
- Molecular formula:C5H2Cl2N2O2
- Molecular Weight:192.99
372118-01-9
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Yield:1040246-87-4 98%
Reaction Conditions:
with lithium hydroxide in tetrahydrofuran at 0; for 0.666667 h;
Steps:
4
To a solution of methyl 4,6-dichloropyridazine-3-carboxylate (5.5 g, 26.6 mmol) in THF (60 mL), at 0° C. was added 1M solution of lithium hydroxide (39.9 mL, 39.9 mmol) with stirring.
The resultant mixture was stirred continuously at 0° C. for 40 min.
The THF was removed and the aqueous layer was acidified with 1.5N HCl to give a white solid.
The mixture was filtered and the solid filter cake was washed with water and dried under vacuum overnight to give 4,6-dichloropyridazine-3-carboxylic acid (5 g, 25.9 mmol, 98% yield).
MS (M+1) m/z: 193 (MH+). LC retention time 0.19 min [D].
References:
BRISTOL-MYERS SQUIBB COMPANY;Liu, Chunjian;Yang, Michael G.;Xiao, Zili;Chen, Ling;Moslin, Ryan M.;Tokarski, John S.;Weinstein, David S. US2019/152948, 2019, A1 Location in patent:Paragraph 0418-0419; 0414
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372118-00-8
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1830-54-2
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