4-Amino-3-isobutylpyrimidine-2,6-dione synthesis
- Product Name:4-Amino-3-isobutylpyrimidine-2,6-dione
- CAS Number:56075-75-3
- Molecular formula:C8H13N3O2
- Molecular Weight:183.21
592-17-6
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$209.00/10g
372-09-8
371 suppliers
$24.73/10gm:
56075-75-3
40 suppliers
$28.60/50MG
Yield:56075-75-3 44.7 g (70%)
Reaction Conditions:
with sodium hydroxide;acetic anhydride in water;
Steps:
3.a a.
a. Preparation of 6-amino-1-(2-methylpropyl)-2,4,-(1H,3H)-pyrimidinedione (XIV) To a solution of 47 g (0.55 mol) cyanoacetic acid and 100 ml of acetic anhydride was added 58 g (0.5 mol) of 2-methylpropylurea. The solution was stirred at 60°-70° C. for 2 hours. After cooling white crystals were filtered off and washed with ethanol. Yield 64.8 g (71%) (XIII). This was stirred in 500 ml of hot water and 20 ml of 5 N NaOH were added in portions so the solution the whole time was basic. The reaction mixture was refluxed for 20 minutes and then neutralized with 5 N HCl. After cooling, white crystals were filtered off. Yield 44.7 g (70%) (XIV), NMR.
References:
US4325956,1982,A
592-17-6
54 suppliers
$209.00/10g
105-56-6
461 suppliers
$10.00/5ml
56075-75-3
40 suppliers
$28.60/50MG