6-Aminouracil synthesis
- Product Name:6-Aminouracil
- CAS Number:873-83-6
- Molecular formula:C4H5N3O2
- Molecular Weight:127.1
Yield:873-83-6 96.9%
Reaction Conditions:
Stage #1: methyl 2-cyanoacetatewith sodium in methanol at 20; for 0.5 h;
Stage #2: urea in methanol; for 2 h;Reflux;
Steps:
1; 3 Example 1
Using methyl cyanoacetate as raw material and dimethyl sulfate as methylation reagent In a three-necked flask, add 100 mmol of sodium metal fragments and 50 mL of anhydrous methanol, and stir vigorously to completely dissolve the sodium block; add 50 mmol (0.5 h) of methyl cyanoacetate dropwise at room temperature, and keep the reaction at room temperature for 30 min, add 50 mmol of urea, and reflux to react 3h. Cooled to room temperature, filtered, the filter cake was washed with a small amount of anhydrous methanol and dissolved in 25mL of water, adjusted to neutral with glacial acetic acid, continued stirring for 2h, filtered, and the filter cake was dried to give a light yellow solid 4-amino-2,6 (1H , 3H) pyrimidinedione 5.46g, yield 96.9%.
References:
CN111039876,2020,A Location in patent:Paragraph 0027-0030; 0041-0043
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