ChemicalBook CAS DataBase List 4'-Bromo-2'-fluoroacetanilide

4'-Bromo-2'-fluoroacetanilide synthesis

6synthesis methods

Product Name:4'-Bromo-2'-fluoroacetanilide
CAS Number:326-66-9
Molecular formula:C8H7BrFNO
Molecular Weight:232.05

367-24-8 Synthesis

367-24-8
482 suppliers
$15.00/25 g

75-36-5 Synthesis

75-36-5
558 suppliers
$17.92/100G

326-66-9
160 suppliers
$15.00/5 g

Yield: 99%

Reaction Conditions:

with triethylamine in dichloromethane at 0 - 20; for 8 h;

Steps:

To a solution of 4- bromo-2-fluoroaniline (2.0g, 10.51 mmol) in dichloromethane (20 ml) cooled to 0°C, triethylamine ( 2.90 ml, 21.02) was added followed by acetyl chloride ( 0.90 ml, 12.61 mol). After stirring at room temperature for 8h, the reaction mixture was quenched with water, extracted with dichloromethane, dried over sodium sulphate and concentrated to afford the title compound as a off-white solid ( 2.60g, 99%) which was used as such in next step.

References:

RHIZEN PHARMACEUTICALS SA;NAGARATHNAM, Dhanapalan;VAKKALANKA, Swaroop Kumar, V.S.;MUTHUPPALANIAPPAN, Meyyappan;VISWANADHA, Srikant;BABU, Govindarajulu;BHAVAR, Prashant, Kashinath WO2012/151525, 2012, A1 Location in patent:Page/Page column 122

399-31-5 Synthesis