ChemicalBook CAS DataBase List 4-Bromo-2-methyl-6-nitroaniline

4-Bromo-2-methyl-6-nitroaniline synthesis

5synthesis methods

Product Name:4-Bromo-2-methyl-6-nitroaniline
CAS Number:77811-44-0
Molecular formula:C7H7BrN2O2
Molecular Weight:231.05

570-24-1 Synthesis

570-24-1
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77811-44-0
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Yield:77811-44-0 97.7%

Reaction Conditions:

with hydrogen bromide;dihydrogen peroxide in ethanol;water at 60; for 1 h;Product distribution / selectivity;

Steps:

17

Aqueous hydrobromic acid (48 wt%, 1.1 molar equivalents) was added at room temperature to an 18.1 wt% solution of 2-methyl-6-nitroaniline (6O g) in ethanol/water (70:30 v/v). The mixture was warmed to 60 °C and hydrogen peroxide (30 wt% in water, 1.2 molar equivalents) was added. The mixture was stirred at 60 °C for 1 h and the cooled to room temperature. The precipitated product was filtered off, washed with ethanol and dried. Yield: 97.7%

References:

WO2010/81670,2010,A2 Location in patent:Page/Page column 24