4-BROMO-4'-(DIPHENYLAMINO)BIPHENYL synthesis
- Product Name:4-BROMO-4'-(DIPHENYLAMINO)BIPHENYL
- CAS Number:202831-65-0
- Molecular formula:C24H18BrN
- Molecular Weight:400.31
105946-82-5
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122-39-4
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202831-65-0
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$19.00/250mg
Yield: 78%
Reaction Conditions:
with dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;sodium t-butanolate in tolueneInert atmosphere;Reflux;Sonication;
Steps:
1 Example 1: Preparation of Intermediate A-1
Compound I-1 (12.5 g, 73.8 mmol), 4-bromo-4'-iodide (26.5 g, 73.8 mmol) were sequentially added to a round bottom flask.t-BuONa (10.7 g, 111 mmol), Pd(dppf)Cl2.CH2Cl2 (1.2 g, 1.47 mmol), and ultrasonically deoxygenated toluene (1.5 L) were refluxed under nitrogen atmosphere overnight. After cooling the reaction solution, ethyl acetate was used. Ester and water treatment, and the resulting organic layer was dried over MgSO 4Evaporate the solvent under reduced pressureThe crude product of compound II-1 was obtained.With silicone as the stationary phase,Dichloromethane/hexane as eluent,The crude product is subjected to column chromatography.Compound II-1 (23.0 g, 78%) was obtained.
References:
Changchun Hai Purunsi Technology Co., Ltd.;Liu Xiqing;Sun Jing CN107827873, 2018, A Location in patent:Paragraph 0048; 0049; 0050
589-87-7
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201802-67-7
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$6.00/1g
202831-65-0
153 suppliers
$19.00/250mg
92-86-4
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122-39-4
358 suppliers
$14.00/5g
202831-65-0
153 suppliers
$19.00/250mg
267221-88-5
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$10.00/250mg
589-87-7
540 suppliers
$10.00/1g
202831-65-0
153 suppliers
$19.00/250mg
106-37-6
487 suppliers
$9.00/5g
201802-67-7
282 suppliers
$6.00/1g
202831-65-0
153 suppliers
$19.00/250mg