4-BROMO-4'-METHYLBENZENESULFONANILIDE synthesis
- Product Name:4-BROMO-4'-METHYLBENZENESULFONANILIDE
- CAS Number:7454-58-2
- Molecular formula:C13H12BrNO2S
- Molecular Weight:326.21
Yield:7454-58-2 70%
Reaction Conditions:
with copper (I) cyanide;Ir(ppy)3 in acetonitrile at 20; for 24 h;Schlenk technique;Irradiation;Inert atmosphere;
Steps:
General procedure for the synthesis of products 3
General procedure: Arylsulfinic acid 2 (0.10 mmol), Ir(ppy)3 (1.0 mol%) and CuCN (10 mol%) wereadded to a 10 mL schlenk tube. Under the protection of N2, azide (0.11 mmol) andCH3CN (1.0 mL) were then dropped to the schlenk tube equipped with a stirring bar.The solution was stirred at a distance of 1.5 cm from a 24 W blue LED lamp at roomtemperature for 24 h. The reaction system was extracted with EtOAc (3 x 10 mL),washed with saturated NaCl solution (10 mL), dried over Na2SO4, and concentrated theorganic layer under reduced pressure. The product was purified by flashchromatography.
References:
Liang, Zhipeng;Wu, Ya-Nan;Wang, Yang [Molecules,2022,vol. 27,# 17,art. no. 5539] Location in patent:supporting information
