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p-Toluidine

p-Toluidine
p-Toluidine structure
CAS No.
106-49-0
Chemical Name:
p-Toluidine
Synonyms
ci37107;c.i.37107;tolyamine;р-Touidin;NSC 15350;p-Toluidin;Tolylamine;NSC 114040;р-Touidine;P-TOLUIDINE
CBNumber:
CB8381150
Molecular Formula:
C7H9N
Formula Weight:
107.15
MOL File:
106-49-0.mol

p-Toluidine Properties

Melting point:
41-46 °C(lit.)
Boiling point:
200 °C(lit.)
Density 
0.973 g/mL at 25 °C(lit.)
vapor density 
3.9 (vs air)
vapor pressure 
0.26 mm Hg ( 25 °C)
refractive index 
1.5636
Flash point:
192 °F
storage temp. 
Store below +30°C.
solubility 
Soluble in ethanol, pyridine, diethyl ether, acetone, carbon tetrachloride, methanol, carbon disulfide, oils and dilute acids.
pka
5.08(at 25℃)
form 
powder
color 
tan to brown
Specific Gravity
0.962
explosive limit
6.6%
Water Solubility 
1.1 g/100 mL
Sensitive 
Air & Light Sensitive
Merck 
14,9536
BRN 
471281
Exposure limits
TLV-TWA skin 2 ppm (~9 mg/m3) (ACGIH); Suspected Human Carcinogen (ACGIH).
Stability:
Stable. Incompatible with strong oxidizing agents, strong acids.
CAS DataBase Reference
106-49-0(CAS DataBase Reference)
EWG's Food Scores
3-4
FDA UNII
I1D0KL7I4U
NIST Chemistry Reference
p-Toluidine(106-49-0)
EPA Substance Registry System
p-Toluidine (106-49-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H311+H331-H317-H319-H334-H351-H410-H301-H311-H331-H400
Precautionary statements  P261-P280-P302+P352+P312-P304+P340+P312-P403+P233-P273-P301+P310-P305+P351+P338-P311-P284-P301+P310+P330-P342+P311-P280h-P302+P352-P309-P310
Hazard Codes  T,N
Risk Statements  23/24/25-36-40-43-50
Safety Statements  28-36/37-45-61-28A
RIDADR  UN 3451 6.1/PG 2
WGK Germany  2
RTECS  XU3150000
8-23
Autoignition Temperature 899 °F
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  38220000
Toxicity LD50 orally in Rabbit: 336 mg/kg LD50 dermal Rabbit 890 mg/kg
NFPA 704
2
3 0

p-Toluidine price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.08315 p-Toluidine for synthesis 106-49-0 250 g $24.7 2021-03-22 Buy
Sigma-Aldrich 8.08315 p-Toluidine for synthesis 106-49-0 5 g $14.15 2021-03-22 Buy
Sigma-Aldrich 8.08315 p-Toluidine for synthesis 106-49-0 1 kg $67.43 2021-03-22 Buy
Sigma-Aldrich 236314 p-Toluidine 99.6% 106-49-0 25g $90.3 2021-03-22 Buy
Sigma-Aldrich 1.10841 p-Toluidine GR for analysis 106-49-0 50 g $426.42 2021-03-22 Buy

p-Toluidine Chemical Properties,Uses,Production

Chemical Properties

White lustrous plates or leaflets. Soluble in alcohol and ether; very slightly soluble in water. Combustible.

Chemical Properties

p-Toluidine is a colorless solid.

Uses

p-Toluidine is used as an intermediate in themanufacture of various dyes. It is also usedas a reagent for lignin and nitrites.

Uses

Manufacture of various dyes and other organic chemicals. o-Isomer also in printing textiles blue black; making colors fast to acids. p-Isomer also as a reagent for lignin, nitrite, phloroglucinol.

Definition

ChEBI: An aminotoluene in which the amino substituent is para to the methyl group.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 2759, 1991 DOI: 10.1016/0040-4039(91)85078-J
Journal of the American Chemical Society, 89, p. 5311, 1967 DOI: 10.1021/ja00996a055

General Description

Colorless solid. Melting point 44°C (111°F). Specific gravity 1.046. Vapor heavier than air. Produces toxic oxides of nitrogen during combustion. May be absorbed through the skin. Used in dyes, and in organic chemical manufacturing.

Reactivity Profile

p-Toluidine neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. Can react vigorously with oxidizing reagents. Emits very toxic fumes of oxides of nitrogen when heated to decomposition. Hypergolic reaction with red fuming nitric acid [Kit and Evered, 1960, p. 239, 242].

Health Hazard

Absorption of toxic quantities by any route causes cyanosis (blue discoloration of lips, nails, skin); nausea, vomiting, and coma may follow. Repeated inhalation of low concentrations may cause pallor, low-grade secondary anemia, fatigability, and loss of appetite. Contact with eyes causes irritation.

Health Hazard

p-Toluidine is a mild to moderate irritanton the skin. The irritant effect on rabbits’eyes was strong. The toxic properties ofp-toluidine are similar to its ortho- and meta isomers and aniline. The clinical signs of tox icity are methemoglobinemia, anemia, andcyanosis. The major metabolite in urine afteroral application in male rats was 2-amino-5-methylphenol, which was excreted alongwith 3.5% unchanged p-toluidine (ACGIH1986). Exposure to 40-ppm concentrationfor 1 hour resulted in severe poisoning inhumans.

Fire Hazard

Special Hazards of Combustion Products: Toxic and flammable vapors may form in fire.

Safety Profile

Confirmed carcinogen. Poison by ingestion and intraperitoneal routes. Mutation data reported. A severe skin and eye irritant. Flammable when exposed to heat, flame, or oxidizers. Can react vigorously on contact with oxidzing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of NOx. See also o- TOLUIDINE and ANILINE.

Potential Exposure

para-Toluidine is used in dyes, and in organic chemical manufacturing

Carcinogenicity

In an 18-month p-toluidine hydrochloride diet carcinogenicity study, maleCDrats (1000 and 2000 ppmfor 18 months) did not develop statistically significant increases of tumors; however,CD-1male and female mice (1000 ppmfor 6 months and then 500 ppmfor additional 12 months; or 2000 ppm for 6 months and then 1000 ppm for additional 12 months) showed significant increases in liver carcinomas: in males at both dose levels and in females at the high dose level.

Shipping

UN3451 Toluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

In general, methods similar to those for purifying aniline can be used. It can be separated from the o-and m-isomers by fractional crystallisation from its melt. p-Toluidine has been crystallised from hot water (charcoal), EtOH, *benzene, pet ether or EtOH/water (1:4), and dried in a vacuum desiccator. It can also be sublimed at 30o under vacuum. For further purification, use has been made of the oxalate, the sulfate and acetylation. The oxalate, formed as described for o-toluidine, is filtered, washed and recrystallised three times from hot distilled water. The base is regenerated with aqueous Na2CO3 and recrystallised three times from distilled water. [Berliner & May J Am Chem Soc 49 1007 1927.] Alternatively, p-toluidine is converted to its acetyl derivative which, after repeated crystallisation from EtOH, is hydrolysed by refluxing (50g) in a mixture of 500mL of water and 115mL of conc H2SO4 until a clear solution is obtained. The amine sulfate is isolated, suspended in water, and NaOH is added. The free base is distilled twice from zinc dust under vacuum. The p-toluidine is then recrystallised from pet ether and dried in a vacuum desiccator or in a vacuum for 6hours at 40o. The benzoyl derivative has m 158o (from EtOH). [Berliner & Berliner J Am Chem Soc 76 6179 1954, Moore et al. J Am Chem Soc 108 2257 1986, Beilstein 12 H 880, 12 I 140, 12 II 482, 12 III 2017, 12 IV 1866.]

Incompatibilities

para-Toluidine is incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. p-Toluidine neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. Hypergolic reaction with red fuming nitric acid

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices).

p-Toluidine Preparation Products And Raw materials

Raw materials

Preparation Products


p-Toluidine Suppliers

Global( 290)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20914 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880623
022-66880086 sales@tjzxchem.com CHINA 537 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5892 58
Shanghai Worldyang Chemical Co.,Ltd.
+86-13651600618
CHINA 832 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58

View Lastest Price from p-Toluidine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-02 p-toluidine
106-49-0
US $476.20 / KG 1KG 99% 800kg Baoji Guokang Healthchem co.,ltd
2021-08-26 P-Toluidine
106-49-0
US $10.00 / Kg/Drum 1KG 98% 10 ton Hebei Crovell Biotech Co Ltd
2021-06-16 p-Toluidine
106-49-0
US $25.00 / pc 100G 99.5% 100 mt Hebei Guanlang Biotechnology Co., Ltd.

p-Toluidine Spectrum


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