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p-Toluidine structure
Chemical Name:
ci37107;c.i.37107;tolyamine;NSC 15350;р-Touidin;р-Touidine;p-Toluidin;Tolylamine;NSC 114040;p-toluidyna
Molecular Formula:
Formula Weight:
MOL File:

p-Toluidine Properties

Melting point:
41-46 °C(lit.)
Boiling point:
200 °C(lit.)
0.973 g/mL at 25 °C(lit.)
vapor density 
3.9 (vs air)
vapor pressure 
0.26 mm Hg ( 25 °C)
refractive index 
Flash point:
192 °F
storage temp. 
Soluble in ethanol, pyridine, diethyl ether, acetone, carbon tetrachloride, methanol, carbon disulfide, oils and dilute acids.
5.08(at 25℃)
Specific Gravity
tan to brown
explosive limit
Water Solubility 
1.1 g/100 mL
Air & Light Sensitive
Exposure limits
TLV-TWA skin 2 ppm (~9 mg/m3) (ACGIH); Suspected Human Carcinogen (ACGIH).
Stable. Incompatible with strong oxidizing agents, strong acids.
CAS DataBase Reference
106-49-0(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
Benzenamine, 4-methyl-(106-49-0)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,N
Risk Statements  23/24/25-36-40-43-50
Safety Statements  28-36/37-45-61-28A
RIDADR  UN 3451 6.1/PG 2
WGK Germany  2
RTECS  XU3150000
Autoignition Temperature 899 °F
HazardClass  6.1
PackingGroup  II
HS Code  38220000
Hazardous Substances Data 106-49-0(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 336 mg/kg LD50 dermal Rabbit 890 mg/kg
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P309 IF exposed or if you feel unwell:
P310 Immediately call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

p-Toluidine price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 236314 p-Toluidine 99.6% 106-49-0 25g $99.3 2018-11-22 Buy
Sigma-Aldrich 1672053 p-Toluidine United States Pharmacopeia (USP) Reference Standard 106-49-0 50mg $1090 2018-11-20 Buy
TCI Chemical T0300 p-Toluidine >99.0%(GC)(T) 106-49-0 25g $22 2018-11-22 Buy
TCI Chemical T0300 p-Toluidine >99.0%(GC)(T) 106-49-0 500g $78 2018-11-22 Buy
Alfa Aesar A13698 p-Toluidine, 99+% 106-49-0 250g $22.4 2018-11-13 Buy

p-Toluidine Chemical Properties,Uses,Production

Chemical Properties

White lustrous plates or leaflets. Soluble in alcohol and ether; very slightly soluble in water. Combustible.

Chemical Properties

p-Toluidine is a colorless solid.


p-Toluidine is used as an intermediate in themanufacture of various dyes. It is also usedas a reagent for lignin and nitrites.


ChEBI: An aminotoluene in which the amino substituent is para to the methyl group.


Manufacture of various dyes and other organic chemicals. o-Isomer also in printing textiles blue black; making colors fast to acids. p-Isomer also as a reagent for lignin, nitrite, phloroglucinol.

General Description

Colorless solid. Melting point 44°C (111°F). Specific gravity 1.046. Vapor heavier than air. Produces toxic oxides of nitrogen during combustion. May be absorbed through the skin. Used in dyes, and in organic chemical manufacturing.

Reactivity Profile

p-Toluidine neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. Can react vigorously with oxidizing reagents. Emits very toxic fumes of oxides of nitrogen when heated to decomposition. Hypergolic reaction with red fuming nitric acid [Kit and Evered, 1960, p. 239, 242].

Health Hazard

Absorption of toxic quantities by any route causes cyanosis (blue discoloration of lips, nails, skin); nausea, vomiting, and coma may follow. Repeated inhalation of low concentrations may cause pallor, low-grade secondary anemia, fatigability, and loss of appetite. Contact with eyes causes irritation.

Health Hazard

p-Toluidine is a mild to moderate irritanton the skin. The irritant effect on rabbits’eyes was strong. The toxic properties ofp-toluidine are similar to its ortho- and meta isomers and aniline. The clinical signs of tox icity are methemoglobinemia, anemia, andcyanosis. The major metabolite in urine afteroral application in male rats was 2-amino-5-methylphenol, which was excreted alongwith 3.5% unchanged p-toluidine (ACGIH1986). Exposure to 40-ppm concentrationfor 1 hour resulted in severe poisoning inhumans.

Fire Hazard

Special Hazards of Combustion Products: Toxic and flammable vapors may form in fire.

Safety Profile

Confirmed carcinogen. Poison by ingestion and intraperitoneal routes. Mutation data reported. A severe skin and eye irritant. Flammable when exposed to heat, flame, or oxidizers. Can react vigorously on contact with oxidzing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of NOx. See also o- TOLUIDINE and ANILINE.

Potential Exposure

para-Toluidine is used in dyes, and in organic chemical manufacturing

First aid

Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24-48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.


UN3451 Toluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

In general, methods similar to those for purifying aniline can be used. It can be separated from the o-and m-isomers by fractional crystallisation from its melt. p-Toluidine has been crystallised from hot water (charcoal), EtOH, *benzene, pet ether or EtOH/water (1:4), and dried in a vacuum desiccator. It can also be sublimed at 30o under vacuum. For further purification, use has been made of the oxalate, the sulfate and acetylation. The oxalate, formed as described for o-toluidine, is filtered, washed and recrystallised three times from hot distilled water. The base is regenerated with aqueous Na2CO3 and recrystallised three times from distilled water. [Berliner & May J Am Chem Soc 49 1007 1927.] Alternatively, p-toluidine is converted to its acetyl derivative which, after repeated crystallisation from EtOH, is hydrolysed by refluxing (50g) in a mixture of 500mL of water and 115mL of conc H2SO4 until a clear solution is obtained. The amine sulfate is isolated, suspended in water, and NaOH is added. The free base is distilled twice from zinc dust under vacuum. The p-toluidine is then recrystallised from pet ether and dried in a vacuum desiccator or in a vacuum for 6hours at 40o. The benzoyl derivative has m 158o (from EtOH). [Berliner & Berliner J Am Chem Soc 76 6179 1954, Moore et al. J Am Chem Soc 108 2257 1986, Beilstein 12 H 880, 12 I 140, 12 II 482, 12 III 2017, 12 IV 1866.]


para-Toluidine is incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. p-Toluidine neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. Hypergolic reaction with red fuming nitric acid

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices).

p-Toluidine Preparation Products And Raw materials

Raw materials

Preparation Products

p-Toluidine Suppliers

Global( 232)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880086 CHINA 559 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 4525 58
(323) 306-3136
(626) 453-0409 United States 8430 58
career henan chemical co
+86-371-86658258 CHINA 19997 58
Shanghai Excellent Chemical Co., Ltd. 0086-21-33559231; 018964673308 qq48685515;Skype: excellentchem
0086-21-33559231 China 2109 59
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 China 25106 65
Tianjin Zhongxin Chemtech Co., Ltd. 86(0)22-89880739
86(0)22-89880739 ext 8030 / 86-22-66880086 China 553 60

View Lastest Price from p-Toluidine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 p-Toluidine
US $1.00 / kg 1kg 95%-99% 100kg career henan chemical co

p-Toluidine Spectrum

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