4-BroMo-4'-Methylbiphenyl synthesis
- Product Name:4-BroMo-4'-Methylbiphenyl
- CAS Number:844856-52-6
- Molecular formula:C13H11Br
- Molecular Weight:247.13
108-36-1
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5720-05-8
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844856-52-6
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19399-68-9
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Yield:844856-52-6 27% ，19399-68-9 68%
Reaction Conditions:
with disodium[(N,N’-bis(2-hydroxy-5-sulfonatobenzyl)-1,2-diphenyl-1,2-diaminoethano)palladate(II)];caesium carbonate in water at 80; for 1 h;Suzuki-Miyaura Coupling;
Steps:
Catalysis experiments and gas chromatographic analysis of the reaction mixtures
General procedure: Stock solutions of the catalysts (Na2[Pd(HSS)], Na2[Pd(PrHSS)], Na2[Pd(BuHSS)],Na2[Pd(dPhHSS)], rac-Na2[Pd(CyHSS)], Na2[Pd(cis-CyHSS)]) Na2[Pd(trans-CyHSS)]) were prepared by dissolving 5.0×10-7 mol complex in 6 mL water. In general, 0.5 mmol aryl-halide, 0.75 mmol boronic acid derivative (1.5 mmol in the reactions of aryl-dihalides), and 0.5 mmolbase (Cs2CO3) were used in each reaction. Good quality distilled water was used as solvent, the organic phase was comprised of the substrates. 3 mL of water was used in each reaction. The reactions were carried out at 80 °C in 30-120 min reaction time. At the end of the reactions, the mixtures were allowed to cool to room temperature and then were extracted by chlorofom (2 mL). After separation of the phases (15-20 min) the organic phase was removed by a Pasteur pipette and filtered through a short MgSO4 plug.
References:
Bunda, Szilvia;Joó, Ferenc;Kathó, ágnes;Udvardy, Antal;Voronova, Krisztina [Molecules,2020,vol. 25,# 17] Location in patent:supporting information
106-38-7
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844856-52-6
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108-86-1
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459-44-9
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844856-52-6
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50670-49-0
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154542-81-1
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