4-(Chloromethyl)thiazole synthesis
- Product Name:4-(Chloromethyl)thiazole
- CAS Number:3364-76-9
- Molecular formula:C4H4ClNS
- Molecular Weight:133.6
7709-58-2
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Yield:-
Reaction Conditions:
with sodium hydrogencarbonate in water
Steps:
6
The l-(l,3-thiazol-4-ylmethyl)-lH-indol-5-amine used as starting material was made from 5~nitroindole and 4~(chloromethyl)-l,3-thiazole (isolated from 4-(chloromethyl)-l,3- thiazole hydrochloride by neutralisation by aqueous sodium bicarbonate, extraction with dichloromethane, drying of the organic layer with magnesium sulfate and evaporation of the solvent) according to the procedure described in Example 4
References:
ASTRAZENECA AB;ASTRAZENECA UK LIMITED WO2007/34143, 2007, A1 Location in patent:Page/Page column 74
