4-(CHLOROSULFONYL)BENZOIC ACID synthesis
- Product Name:4-(CHLOROSULFONYL)BENZOIC ACID
- CAS Number:10130-89-9
- Molecular formula:C7H5ClO4S
- Molecular Weight:220.63
98-59-9
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10130-89-9
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$7.00/250mg
Yield:10130-89-9 55%
Reaction Conditions:
with chromium(VI) oxide;acetic anhydride;acetic acid at 20 - 40; for 2 h;
Steps:
30a
Step 30a: 4-(Chlorosulfonyl)benzoic acid (Compound 1402)To a solution of p-toluenesulfonyl chloride (1.9 g, 0.01 mol) in HAcZAc2O (20 ml/ 10 ml) was added chromium (VI) oxide (3.0 g, 0.03 mol) in portions at room temperature. The mixture was heated to 40°C for 2 h. and then the reaction mixture was poured into ice water, filtered, and dried to afford product 1402 (1.2 g, 55%): LCMS: 221 [M+l]+. 1H NMR (400MHz, DMSO-d6) δ 7.71 (d, J= 2.0 Hz, 2H), 7.92 (d, J= 6.0 Hz, 2H), 13.92 (s, IH).
References:
CURIS, INC. WO2009/36016, 2009, A1 Location in patent:Page/Page column 85
104-15-4
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10130-89-9
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$7.00/250mg
5399-63-3
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$17.67/5gm:
10130-89-9
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$7.00/250mg
150-13-0
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10130-89-9
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138-41-0
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$11.00/25g
10130-89-9
177 suppliers
$7.00/250mg