
(4-CYANOBENZYL)PHOSPHONIC ACID DIETHYL ESTER synthesis
- Product Name:(4-CYANOBENZYL)PHOSPHONIC ACID DIETHYL ESTER
- CAS Number:1552-41-6
- Molecular formula:C12H16NO3P
- Molecular Weight:253.23

874-89-5
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122-52-1
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1552-41-6
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Yield: 80%
Reaction Conditions:
with tetra-(n-butyl)ammonium iodide at 120; for 24 h;Inert atmosphere;
Steps:
4 Example 4 Triethyl phosphite and 4-cyanobenzyl alcohol were used to prepare diethyl 4- (cyano) benzylphosphonate
To a 20 mL tubular reactor was added 4-cyanobenzyl alcohol (66.5 mg, 0.50 mmol)Triethyl phosphite (166.0 mg, 1.0 mmol, 2.0 equiv.) And tetrabutylammonium iodide (3.7 mg, 0.01 mmol, 2 mol%), vacuum nitrogenAnd then heated to 120 ° C for 24 h under solvent-free conditions. TLC monitoring reaction is complete,The product was purified by column chromatography and the yield was 80%.
References:
Wenzhou University;Xu Qing;Ma Xiantao;Su Chenliang;Han Libiao CN106543221, 2017, A Location in patent:Paragraph 0034; 0035; 0036; 0037

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1552-41-6
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17201-43-3
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122-52-1
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1552-41-6
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$45.00/50mg
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1000210-73-0
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3058-39-7
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1552-41-6
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$45.00/50mg

1067-71-6
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3058-39-7
281 suppliers
$10.00/1g

1552-41-6
79 suppliers
$45.00/50mg