4-DIETHYLAMINOPHENYL ISOTHIOCYANATE synthesis
- Product Name:4-DIETHYLAMINOPHENYL ISOTHIOCYANATE
- CAS Number:84381-54-4
- Molecular formula:C11H14N2S
- Molecular Weight:206.31
Yield:-
Reaction Conditions:
in dichloromethane at 20; for 1 h;
Steps:
4.1.16. Step 3 Tert-butyl 4-(4-isothiocyanatophenyl)piperazine-1-carboxylate (3a)
General procedure: To a solution of 2a (1.0 g, 3.6 mmol) in dichloromethane (30 mL)was added 1,1′-thiocarbonyldiimidazole (1.2 g, 7.2 mmol) at roomtemperature. The reaction mixture was stirred at room temperature for1 h. The solvent was removed in vacuo and the residue was purified bysilica gel chromatography (Developing solvent: petroleum ether (PE)/ethyl acetate (EA)=20/1) to give 3a (1.0 g, yield 87.2%).
References:
Bao, Jiyin;Liu, Haichun;Zhi, Yanle;Yang, Wenqianzi;Zhang, Jiawei;Lu, Tao;Wang, Yue;Lu, Shuai [Bioorganic Chemistry,2020,vol. 94,art. no. 103248]
75-15-0
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93-05-0
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$11.00/1g
84381-54-4
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$20.00/1g
2216-15-1
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84381-54-4
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350-46-9
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84381-54-4
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96989-50-3
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93-05-0
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$11.00/1g
84381-54-4
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$20.00/1g