ChemicalBook CAS DataBase List 4-FLUOROBENZOIC ANHYDRIDE

4-FLUOROBENZOIC ANHYDRIDE synthesis

6synthesis methods

Product Name:4-FLUOROBENZOIC ANHYDRIDE
CAS Number:25569-77-1
Molecular formula:C14H8F2O3
Molecular Weight:262.21

456-22-4

25569-77-1

GENERAL METHOD: p-Fluorobenzoic acid (1 mmol) was dissolved in anhydrous CH3CN (5 mL) with K2CO3 (1.5 mmol, 0.20 g), followed by the addition of TsCl (0.5 mmol, 0.10 g). The reaction mixture was stirred at room temperature for appropriate time (20-180 min, see Table 2) until TLC detection showed complete consumption of TsCl. After completion of the reaction, CH2Cl2 or Et2O (2 × 10 mL) was added to the mixture, stirred thoroughly and filtered. The organic layer was dried with CaCl2 and the solvent was subsequently evaporated to give high purity 4-fluorobenzoic anhydride.

456-22-4 Synthesis

456-22-4
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$10.00/100 g

25569-77-1
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$13.00/250mg

Yield:25569-77-1 95%

Reaction Conditions:

with potassium carbonate;p-toluenesulfonyl chloride in acetonitrile at 20; for 2.5 h;

Steps:

3.2. General Procedure for the Preparation of CarboxylicAcid Anhydride Using TsCl in Conventional System
General procedure: TsCl (0.5 mmol, 0.10 g) was added to the mixture of carboxylic acid (1 mmol) and K₂CO₃ (1.5 mmol, 0.20 g) in dry CH₃CN (5 mL), the reaction mixture was stirred at roomtemperature for the appropriate time (20-180 min, Table 2) until the TsCl was no longer detectable by TLC. After the completion of the reaction, CH₂Cl₂ or Et₂O (2×10 mL) was added to the reaction mixture, stirred, filtered, and the organic layer was dried over CaCl₂. The evaporation of the solvent afforded a highly pure product.

References:

Eskandari, Parvin;Kazemi, Foad [Letters in Organic Chemistry,2017,vol. 14,# 6,p. 431 - 439]

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