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[(4-fluorophenyl)amino](oxo)acetic acid synthesis

4synthesis methods
-

Yield:-

Reaction Conditions:

Stage #1: ethyl 2-(4-fluorophenylamino)-2-oxoacetatewith water;sodium hydroxide in tetrahydrofuran;methanol at 0 - 20;
Stage #2: with hydrogenchloride in water; pH=2;

References:

Yamada, Yuko;Ochiai, Chihiro;Yoshimura, Kazuhisa;Tanaka, Tomohiro;Ohashi, Nami;Narumi, Tetsuo;Nomura, Wataru;Harada, Shigeyoshi;Matsushita, Shuzo;Tamamura, Hirokazu [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 1,p. 354 - 358] Location in patent:experimental part

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