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ChemicalBook CAS DataBase List 4-Hydroxy-6-methylnicotinic acid

4-Hydroxy-6-methylnicotinic acid synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: DMA / dioxane
2.1: aq. NH3
2.2: NHMe2 / 50 °C
2.3: H2SO4

References:

Blackaby, Wesley P.;Atack, John R.;Bromidge, Frances;Lewis, Richard;Russell, Michael G.N.;Smith, Alison;Wafford, Keith;McKernan, Ruth M.;Street, Leslie J.;Castro, Jose L. [Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,# 22,p. 4998 - 5002]

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