4-HYDROXYBENZOIC ACID 4-METHOXYPHENYL ESTER synthesis
- Product Name:4-HYDROXYBENZOIC ACID 4-METHOXYPHENYL ESTER
- CAS Number:50687-62-2
- Molecular formula:C14H12O4
- Molecular Weight:244.24
Yield:50687-62-2 85%
Reaction Conditions:
sulfuric acid in benzene at 100; for 10 h;
Steps:
1
First, 4-hydroxybenzoic acid and 4-methoxyphenol were heated at 100 C. for 10 hours in benzene as a solvent at a mole ratio of 1:1 with a small amount of sulfuric acid added thereto, while removing water. After the completion of the reaction, the organic layer was dissolved in ether and washed with water several times to remove sulfuric acid used to perform the reaction. Next, the organic solvent was dewatered with anhydrous magnesium sulfate, and the resultant product was subjected to distillation under reduced pressure to obtain a yellow solid, which, in turn, was washed with ether several times to obtain a white ester compound at a yield of about 85%.
References:
US7910179,2011,B2 Location in patent:Page/Page column 19-22
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