4-Isopropylthiazole-2-carboxylic acid synthesis
- Product Name:4-Isopropylthiazole-2-carboxylic acid
- CAS Number:300831-06-5
- Molecular formula:C7H9NO2S
- Molecular Weight:171.22
156589-82-1
46 suppliers
$45.00/10mg
300831-06-5
98 suppliers
$104.00/100mg
Yield: 90%
Reaction Conditions:
Stage #1:4-(1-methylethyl)thiazole-2-carboxylic acid ethyl ester with lithium hydroxide;water in tetrahydrofuran;methanol at 20; for 48 h;
Stage #2: with hydrogenchloride in tetrahydrofuran;methanol;water
Steps:
44 4-isopropylthiazole-2-carboxylic acid (44)
To a solution of ethyl 4-isopropylthiazole-2-carboxylate (9.1 g, 46 mmol) in THF (100 ml) and MeOH (30 ml) was added a solution of lithium hydroxide (1.16 g, 48.5 mmol) and the mixture was stirred for two days at room temperature. The mixture was acidified with 2M hydrochloric acid and extracted four times with diethyl ether. The organic phase was dried with sodium sulphate and evaporated under reduced pressure. Yield: 7.1 g, 90%.
References:
Medivir AB US2009/23758, 2009, A1 Location in patent:Page/Page column 54
563-80-4
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$17.00/25mL
300831-06-5
98 suppliers
$104.00/100mg
19967-55-6
129 suppliers
$20.00/100mg
300831-06-5
98 suppliers
$104.00/100mg