4-METHOXY-N-METHYLBENZAMIDE synthesis
- Product Name:4-METHOXY-N-METHYLBENZAMIDE
- CAS Number:3400-22-4
- Molecular formula:C9H11NO2
- Molecular Weight:165.19
104-93-8
400 suppliers
$6.00/25g
74-89-5
0 suppliers
$13.44/25ML
3400-22-4
50 suppliers
$16.00/100mg
Yield:3400-22-4 78%
Reaction Conditions:
with tert.-butylhydroperoxide;iron(III) chloride;tetra-(n-butyl)ammonium iodide in water at 60; for 24 h;Sealed tube;Molecular sieve;Green chemistry;
Steps:
9 Example 9
Add 4-methyl anisole (20 eq) to a clean 10 mL sealed tubeAnd methylamine 40% aqueous solution (0.24mmol),TBHP (70% water) 6 eq as oxidant,30 mol% TBAI and 15 mol% FeCl3 are used as catalysts,100 mg of 4A molecular sieve and 1.5 mL of water.React at 60 oC for 24 hours,TLC dot plate detection, after the reaction, the reaction solution is cooled to room temperature,The reaction solution was extracted with ethyl acetate (3×10 mL),Combine the organic phases and dry with anhydrous Na2SO4,The organic layer is concentrated and column chromatography to obtain pureN-methyl 4-methoxybenzamide, yellow solid, yield 78%.
References:
CN104761420,2021,B Location in patent:Paragraph 0015; 0049-0052
512-56-1
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$16.00/25g
3424-93-9
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$14.00/1g
3400-22-4
50 suppliers
$16.00/100mg
67-56-1
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$9.00/25ml
874-90-8
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$8.00/10g
3400-22-4
50 suppliers
$16.00/100mg
100-07-2
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$35.00/25g
3400-22-4
50 suppliers
$16.00/100mg
593-51-1
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$21.00/100g
100-07-2
401 suppliers
$35.00/25g
3400-22-4
50 suppliers
$16.00/100mg