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Trimethyl phosphate

description Chemical properties uses
Trimethyl phosphate
Trimethyl phosphate structure
Chemical Name:
Trimethyl phosphate
TMP;(CH3O)3PO;NCI-C03781;TriMethylphosp;Trimethylfosfat;METHYL PHOSPHATE;(Lactic acid) TMP;TRIMETHYL PHOSPHATE;Trimethyl phsophate;Basic Water-Soluble TMP
Molecular Formula:
Formula Weight:
MOL File:

Trimethyl phosphate Properties

Melting point:
-46 °C
Boiling point:
197 °C(lit.)
1.197 g/mL at 25 °C(lit.)
vapor pressure 
1.133 hPa (25 °C)
refractive index 
n20/D 1.395(lit.)
Flash point:
107 °C
storage temp. 
Store below +30°C.
Specific Gravity
Water Solubility 
500 G/L (25 ºC)
Moisture Sensitive
CAS DataBase Reference
512-56-1(CAS DataBase Reference)
NIST Chemistry Reference
Phosphoric acid, trimethyl ester(512-56-1)
EPA Substance Registry System
Phosphoric acid, trimethyl ester(512-56-1)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,Xn,Xi
Risk Statements  46-22-40-68-45-20/21/22-38-36
Safety Statements  53-36/37-45-36/37/39-26
RIDADR  2810
WGK Germany  1
RTECS  TC8225000
Hazard Note  Toxic/Moisture Sensitive
HS Code  2919 90 00
Hazardous Substances Data 512-56-1(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 840 mg/kg LD50 dermal Rabbit 3388 mg/kg
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P281 Use personal protective equipment as required.
P309 IF exposed or if you feel unwell:
P310 Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Trimethyl phosphate price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 132195 Trimethyl phosphate 97% 512-56-1 250g $40.3 2018-11-13 Buy
Sigma-Aldrich 132195 Trimethyl phosphate 97% 512-56-1 1kg $109 2018-11-13 Buy
TCI Chemical P0271 Trimethyl Phosphate >98.0%(GC) 512-56-1 25g $15 2018-11-22 Buy
TCI Chemical P0271 Trimethyl Phosphate >98.0%(GC) 512-56-1 500g $46 2018-11-22 Buy
Alfa Aesar A10595 Trimethyl phosphate 98+% 512-56-1 500g $59.4 2018-11-20 Buy

Trimethyl phosphate Chemical Properties,Uses,Production


Trimethyl phosphate (TMP) is a kind of organic reagent, stable at room temperature, good solubility in a variety of resins, low viscosity, low hue, so it can be used as special solvents; such as epoxy resin additives (reduced viscosity); anti stain when processing polyester fiber (To improve the dyeing quality); textile finishing agent; used as gasoline additives, can prevent the detonation, improve the octane number, increase the stability of lead-based gasoline storage; can also be used as a control agent for gasoline surface ignition, tetraethyllead decomposition inhibitor when high temperature; non-corrosive gasoline additive; catalyst for polymerization of polyester fiber; modifier for graphite product; plasticizer; extraction agent; pesticide raw material for pesticide. Trimethyl phosphate hydrolysis occurs in water, so it is necessary to preserve moisture. Because of its hydrolysis and the release of PO43-, thus becoming the homogeneous precipitation agent, which is insoluble phosphate precipitation, is often used as precipitation reagents of zirconium and hafnium and a diffusion source for the determination of semiconductors. In addition, trimethyl phosphate is also a phospholipid extractant for the extraction and separation of certain metal ions.

Chemical properties

Trimethyl phosphate is a colorless transparent liquid, soluble in water, soluble in ether, but insoluble in ethanol.


(1) Trimethyl phosphate used as a reagent for determination of zirconium, solvent, extractant and gas chromatography stationary phase.
(2) It is mainly used as medicine and solvent and extraction agent of pesticide. Pesticide intermediates. In Japan, mainly used for textile oil and anti-coloring agent of polymer.
(3) It is used as gas chromatography stationary phase; for the determination of zirconium; used as extraction agent.

Chemical Properties

Colorless liquid; bp 197°C (386°F); density 1.197 at 20°C (68 °F); soluble in most organic solvents, low solubility in water.


TMP is used as an intermediate in organic synthesis. Its industrial applications are much fewer than those of other organic phosphates.


For controlling spark plug fouling, surface ignition and rumble in gasoline engines.

Production Methods

Prepared by the reaction of phosphorus oxychloride with methanol.


ChEBI: A trialkyl phosphate that is the trimethyl ester of phosphoric acid.

General Description

A pale straw colored liquid. Inhalation may irritate or seriously burn respiratory tract. vapor or liquid may irritate or severely burn skin or eyes. Ingestion may irritate or burn the mucous membranes of the gastrointestinal tract.

Reactivity Profile

TRIMETHYL PHOSPHATE may explode when heated. Residue from a large scale atmospheric pressure distillation of Trimethyl phosphate has exploded violently. Trimethyl phosphate is incompatible with nitrates. . Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.


Toxic by ingestion and inhalation, strong irritant to skin and eyes.

Health Hazard

There are no reports on the toxicity of trimethyl phosphate to humans.

Health Hazard

TMP is a mutagen, teratogen, and a cancercausing compound. The health hazard from this compound is somewhat different from those of the higher members of the organic phosphate series. While carcinogenicity is observed only for this phosphate, with mutagenicity and the teratogenic effects being more marked, higher alkyl phosphates are more neurotoxic but noncarcinogenic.
TMP is toxic at high dosages.LD50 value,oral(mice):1470 mg/kg(NIOSH 1986)
Laboratory tests on animals indicated clear evidence of its cancer-causing actions, producing uterine and skin tumors. There is so far no report on such carcinogenic actions in humans. The compound tested positive in mutagenic tests and caused fetal deaths and birth defects in mice, rats, and hamsters when given orally or intraperitoneally..

Fire Hazard

Trimethyl phosphate is nonflammable.

Industrial uses

1 Gasoline additive at 0.25 g/gal for controlling surface ignition and spark plug fouling.
2 Methylating agent, chemical intermediate in the production of polymethyl polyphosphates.
3 Flame retardant solvent for paints and polymers.
4 Catalyst in the preparation of polymers and resins.

Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion, skin contact, intraperitoneal, and intravenous routes. Experimental reproductive effects. Human mutation data reported. Explodes when heat distilled. When heated to decomposition it emits toxic fumes of POx. See also ESTERS.


A system utilizing isolated anterior forearm stratum corneum conjunctum of man to study skin penetrating capacity of a series of organic phosphates was developed. Trimethyl phosphate was tested in the system and had the greatest skin-penetrating capacity of the 8 related compounds tested (Marzulli et al 1965).
Rats treated orally at 100 mg/kg and mice treated i.p. at 1000 mg/kg with [32]P-labeled trimethyl phosphate excreted primarily dimethyl phosphate in the urine. Only traces of the parent compound were detected, and only in the rats at less than 6 h after treatment. S-Methyl cysteine and S-methyl cysteine N-acetate were also isolated. Small amounts of S-methyl glutathione were detected, presumably the initial methylation product in this series of metabolites (Jones 1970). Metabolism of trimethyl phosphate was faster in the mouse than in the rat, but there was no evidence of further conversion to monomethyl phosphate or inorganic phosphate in either species (Jackson and Jones 1968).

Purification Methods

Purify the phosphate by fractionation through an efficient column at high reflux ratio. It is quite soluble in H2O; the solubility is 1:1 at 25o. [Becker J Am Chem Soc 74 2923 1952, IR: Bergmann et al. J Chem Soc 847 1952, McIvor et al. Can J Chem 36 820 1958, Kosolapoff Organophosphorus Compounds, Wiley p 258 1950, and Cherbuliez in Organo Phosphorus Compounds (Kosolapoff & Maier eds) Wiley Vol 6 pp 211-577 1973, Beilstein 1 IV 1259.]

Waste Disposal

TMP is mixed with a combustible solvent and destroyed by burning in a chemical incinerator.

Trimethyl phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

Trimethyl phosphate Suppliers

Global( 208)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1664 55
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20229 58
Jinan Finer Chemical Co., Ltd
+86-531-88989539 CHINA 485 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 4557 58
(323) 306-3136
(626) 453-0409 United States 8430 58
career henan chemical co
+86-371-86658258 CHINA 19997 58
Hebei Ruishun Trade Co.,LTD
17052563120 CHINA 299 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3624 58

View Lastest Price from Trimethyl phosphate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-04 Trimethyl phosphate
US $6.00 / kg 1kg High quality Professional Factory Ms Ella Chemwill Asia Co.,Ltd.
2018-12-18 Trimethyl phosphate
US $1.00 / kg 1kg 99% 2000kg career henan chemical co
2018-10-23 Factory Supply Trimethyl phosphate 98% CAS NO.512-56-1 CAS NO.512-56-1 CAS NO.512-56-1
US $1.00 / G 100G 99.9% 50000 tons Hebei Ruishun Trade Co.,Ltd

Trimethyl phosphate Spectrum

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