ChemicalBook CAS DataBase List 4-Methoxybenzyl cyanide

4-Methoxybenzyl cyanide synthesis

10synthesis methods

Product Name:4-Methoxybenzyl cyanide
CAS Number:104-47-2
Molecular formula:C9H9NO
Molecular Weight:147.17

6343-93-7 Synthesis

6343-93-7
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$27.00/1g

104-47-2
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$6.00/10g

Yield:104-47-2 98%

Reaction Conditions:

with triethylamine;ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate in ethyl acetate at 20; for 1 h;Inert atmosphere;

Steps:

Dehydration of Oximes and Amides to Nitriles; General Procedure
General procedure: To a solution of the aldoxime or the amide (1.0 mmol) and Et3N (1.5mmol) in EtOAc (1 mL, 1 M) at r.t. was added XtalFluor-E8 (1.1 mmol)portionwise over ca. 2 min. The resulting solution was stirred at r.t.for 1 h. The reaction mixture was quenched with sat. aq Na2CO3 and extracted with CH2Cl2 (2 × 10 mL). The combined organic layers were washed with H2O and brine, dried (MgSO4), and concentrated under vacuum to afford the crude nitrile, which was purified by flash chromatography, if required.

References:

Keita, Massaba;Vandamme, Mathilde;Paquin, Jean-François [Synthesis,2015,vol. 47,# 23,art. no. SS-2015-M0394-OP,p. 3758 - 3766]

FullText

773837-37-9 Synthesis