4-Morpholinobenzaldehyde synthesis
- Product Name:4-Morpholinobenzaldehyde
- CAS Number:1204-86-0
- Molecular formula:C11H13NO2
- Molecular Weight:191.23
Yield:1204-86-0 86 %Chromat.
Reaction Conditions:
with C35H34N3OP2PdS(1+)*NO3(1-);sodium t-butanolate in 1,4-dioxane at 100; for 6 h;Catalytic behavior;Buchwald-Hartwig Coupling;
Steps:
2.5.2. General procedure for Buchwald-type C-N coupling reactions
General procedure: In a typical run, an oven-dried 10 ml round bottom flask was charged with a known mole percent of catalyst, NaOtBu (1.3 mmol), amine (1.2 mmol) and aryl halide (1 mmol) with the appropriate solvent(s) (4 ml). The flask was placed in a preheated oil bath at required temp. After the specified time the flask was removed from the oil bath, water (20 ml) was added, and extraction with ether (4×10 ml) was done. The combined organic layers were washed with water (3×10 ml), dried over anhydrous Na2SO4, and filtered. Solvent was removed under vacuum. The residue was dissolved in acetonitrile and analyzed by GC-MS.
References:
Thapa, Kiran;Paul, Piyali;Bhattacharya, Samaresh [Inorganica Chimica Acta,2019,vol. 486,p. 232 - 239]
![Morpholine, 4-[4-(1,3-dioxolan-2-yl)phenyl]-](/CAS/20210305/GIF/773097-39-5.gif)
773097-39-5
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