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ChemicalBook CAS DataBase List 4-Phenoxythiophene-2-carboxylic acid
81028-69-5

4-Phenoxythiophene-2-carboxylic acid synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 50 percent / copper bronze, potassium carbonate / 192 h / Heating
2: 1.) phenyllithium / 1.) ether, benzene, 0 deg C, 5 h, 2.) from -78 deg C to RT

References:

Watthey, Jeffrey W.;Desai, Mahesh [Journal of Organic Chemistry,1982,vol. 47,# 9,p. 1755 - 1759]