4-(piperidine-1-sulfonyl)benzonitrile synthesis
- Product Name:4-(piperidine-1-sulfonyl)benzonitrile
- CAS Number:227935-30-0
- Molecular formula:C12H14N2O2S
- Molecular Weight:250.32
110-89-4
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Yield:227935-30-0 96%
Reaction Conditions:
in dichloromethane;
Steps:
73.A 1-[(4-cyanophenyl)sulfonyl]piperidine
Example 73A 1-[(4-cyanophenyl)sulfonyl]piperidine A mixture of 4-cyanobenzenesulfonyl chloride (0.51 g, 2.5 mmol) and piperidine (0.60 mL, 517 mg, 6.04 mmol) in 10 mL methylene chloride was stirred overnight at ambient temperature. The organic layer was washed successively with water, 5% HCl and brine, dried (Na2 SO4) and concentrated. The resulting white solid (0.61 g, 96%) was used with no further purification.
References:
US6150362,2000,A