ChemicalBook CAS DataBase List 4-Pyridinemethaneamine

4-Pyridinemethaneamine synthesis

9synthesis methods

Product Name:4-Pyridinemethaneamine
CAS Number:3731-53-1
Molecular formula:C6H8N2
Molecular Weight:108.14

872-85-5 Synthesis

872-85-5
481 suppliers
$10.00/1g

3731-53-1
278 suppliers
$6.00/5g

Yield:3731-53-1 94%

Reaction Conditions:

with ammonium hydroxide;hydrogen in acetonitrile at 60; under 3750.38 Torr; for 12 h;

Steps:

10

Add 1 mmol of 4-pyridinecarboxaldehyde, a ruthenium-based catalyst with a molar weight of 16 mol% of 4-pyridinecarboxaldehyde, ammonia water (25wt%) with a molar ratio of 9 to 4-pyridinecarboxaldehyde, and 5 mL of acetonitrile into a 15 mL reaction kettle. The air in the kettle was replaced 5 times, filled with 2.5MPa hydrogen, heated to 60°C, and reacted at this temperature for 12h.After the reaction, according to the method described in Example 1, cooling and sampling analysis,The conversion rate of 4-pyridinecarbaldehyde is 99%,4-PyridinemethanamineGC yield was 98%,The isolated yield was 94%.

References:

CN113717054,2021,A Location in patent:Paragraph 0104; 0106

100-48-1 Synthesis