4-(Sec-butoxy)benzonitrile synthesis
- Product Name:4-(Sec-butoxy)benzonitrile
- CAS Number:86120-21-0
- Molecular formula:C11H13NO
- Molecular Weight:175.23
Yield:86120-21-0 90%
Reaction Conditions:
with water;sodium hydroxide in N,N-dimethyl-formamide at 25; for 0.5 h;Irradiation;
Steps:
Typical procedure for the denitrative etherification of 4-nitrobenzonitrile with ethanol
General procedure: A mixture of 4-nitrobenzonitrile (0.5 mmol), NaOH (4 mmol), and absolute ethanol (2 mmol) were mixed in DMF (3 mL) under white LED irradiation in air atmosphere at 25 °C. The progress of reaction was monitored by thin layer chromatography (TLC). After the completion of reaction, the product was extracted with ethyl acetate/water. The solvent was evaporated leaving the crude product, which was purified by column chromatography over silica gelusing n-hexane/ethyl acetate (8:2) as the eluent.
References:
Soltani, Roghaye;Abdollahi, Fatemeh;Ghaderi, Arash [Journal of Chemical Research,2021,vol. 45,# 1-2,p. 56 - 59]
86120-20-9
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