ChemicalBook CAS DataBase List 4-Thiazolecarboxylic acid

4-Thiazolecarboxylic acid synthesis

10synthesis methods

Product Name:4-Thiazolecarboxylic acid
CAS Number:3973-08-8
Molecular formula:C4H3NO2S
Molecular Weight:129.14

693-95-8

3973-08-8

The general procedure for the synthesis of thiazole-4-carboxylic acid from 4-methylthiazole was as follows: 4-methylthiazole (19.8 g, 0.2 mol), 200 mL of water, and potassium permanganate (173.8 g, 1.1 mol) were added to a 500 mL three-necked flask, which was heated to 55 °C with stirring and kept for 22 hours. After completion of the reaction, the reaction mixture was cooled and filtered. The filter cake (mainly composed of manganese dioxide) was washed with hot water at 50°C. The filtrate was adjusted to pH 3 with dilute hydrochloric acid, precipitated as a solid and filtered. The filter cake was washed with a small amount of water and dried to give 18.1 g of thiazole-4-carboxylic acid in 70.2% yield, melting point 196-198 °C.

693-95-8 Synthesis

693-95-8
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3973-08-8
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Yield:3973-08-8 70.2%

Reaction Conditions:

with potassium permanganate in water at 55; for 22 h;Reagent/catalyst;Temperature;

Steps:

3.3.4 3.4) Synthesis thiazole-4- carboxylic acid
4-methylthiazole (19.8 g, 0.2 mol),200 mL of water and potassium permanganate (173.8 g, 1.1 mol) were placed in a 500 mL three-neck reaction flask and heated to 55° C. for 22 h with stirring and heating.The reaction solution was then cooled and then filtered. The filter cake (manganese dioxide) was washed with hot water at 50°C, and the filtrate was adjusted to pH 3 with dilute hydrochloric acid.A solid precipitated and was filtered. The filter cake was washed with a small amount of water. The product was dried to give 18.1 g, yield 70.2%, melting point 196-198°C.

References:

Yantai Beisen Pharmaceutical Technology Co., Ltd.;Bi Haidong;Zhi Caixia;Zhang Yixing CN104557902, 2018, B Location in patent:Paragraph 0063; 0076; 0081; 0088; 0089; 0102

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